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Table 5 Proportion and grade of most frequent adverse events observed in each arm of the study

From: Pharmacokinetic study of two different rifabutin doses co-administered with lopinavir/ritonavir in African HIV and tuberculosis co-infected adult patients

Clinical

Arm A

Arm B

Adverse Events

Grade

Adverse Events

Grade

Grade 1

Grade 2

Grade 3

Grade 4

Grade 1

Grade 2

Grade 3

Grade 4

Asthenia/fatigue

5/9

4

1

  

3/7

2

1

  

Headaches

4/9

3

1

  

6/7

5

1

  

anorexia

7/9

7

   

3/7

3

   

diarrhoea

1/9

1

1

  

2/7

2

   

Nausea/vomiting

1/9

1

   

3/7

3

   

Arthralgia

1/9

  

1

 

5/7

1

3

1

 

Insomnia

6/9

4

2

  

3/7

2

1

  

vertigo

5/9

4

1

  

0/7

    

Skin rash

5/9

4

1

  

2/7

1

1

  

Death

1/9

   

1

1/7

   

1

Laboratory

 Anaemia

9/9

2

3

2

2

7/7

3

2

1

1

 Leukopenia

3/9

3

   

1/7

1

   

 Neutropenia

1/9

1

   

2/7

1

1

  

 Thrombopenia

0/9

    

1/7

 

2

  

 ALT elevated

6/9

4

2

  

0/7

    

 ASAT elevated

7/9

6

1

  

3/7

3

   

 Amylasemia elevated

3/9

3

   

2/7

 

2

  

 Bilirubinemia T elevated

4/9

4

   

5/7

3

2

  
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BMC Infectious Diseases

ISSN: 1471-2334

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