From: Changes in D-dimer after initiation of antiretroviral therapy in adults living with HIV in Kenya
Total | Normal/low D-dimer (< 500 ng/mL) | High D-dimer (≥ 500 ng/mL) | |||||
---|---|---|---|---|---|---|---|
N | % | N | % | N | % | p-value | |
611 | 100.0 | 300 | 49.1 | 311 | 50.9 | ||
Enrollment D-dimer, median (IQR) | 516.4 (302.7–926.6) | 301.7 (199.0–397-6) | 912.8 (690.2–1446.2) | < 0.0001 | |||
Sex | |||||||
Male | 211 | 34.5 | 117 | 39.0 | 94 | 30.2 | 0.02 |
Female | 400 | 65.5 | 183 | 61.0 | 217 | 69.8 | |
Age (years), median (IQR) | 34 (29–43) | 34 (29–43) | 34 (29–43) | 0.86 | |||
< 25 | 52 | 8.5 | 29 | 9.7 | 23 | 7.4 | 0.60 |
25–40 | 384 | 62.9 | 186 | 62.0 | 198 | 63.7 | |
> 40 | 175 | 28.6 | 85 | 28.3 | 90 | 28.9 | |
CD4+ cells/mm3, median (IQR) | 326 (194–442) | 335 (221–451) | 319 (177–435) | 0.17 | |||
> 500 | 78 | 12.8 | 39 | 13.0 | 39 | 12.5 | 0.42 |
350–500 | 186 | 30.4 | 98 | 32.7 | 88 | 28.3 | |
200–349 | 190 | 31.1 | 95 | 31.7 | 95 | 30.6 | |
< 200 | 156 | 25.5 | 68 | 22.7 | 88 | 28.3 | |
Missing | 1 | 0.2 | 0 | 0.0 | 1 | 0.3 | |
Viral load copies/mL, median (IQR) | 113,500 (23,600-399,000) | 82,200 (15,800-294,000) | 159,000 (33,400-501,000) | 0.0001 | |||
< 1000 (<log 3.0) | 30 | 4.9 | 18 | 6.0 | 12 | 3.9 | 0.01 |
1000–9999 (log 3.0–3.9) | 57 | 9.3 | 34 | 11.3 | 23 | 7.4 | |
10,000–99,999 (log 4.0- < 4.9) | 201 | 32.9 | 107 | 35.7 | 94 | 30.2 | |
100,000-1000,000 (log 5.0–5.9) | 255 | 41.7 | 116 | 38.7 | 139 | 44.7 | |
> 1000,000 (>log 6.0) | 53 | 8.7 | 16 | 5.3 | 37 | 11.9 | |
Missing | 15 | 2.5 | 9 | 3.0 | 6 | 1.9 | |
BMI, median (IQR) | 20.9 (18.9–22.9) | 21.1 (19.1–22.9) | 20.5 (18.6–23.0) | 0.21 | |||
Underweight (< 18.5) | 114 | 18.7 | 48 | 16.0 | 66 | 21.2 | 0.17 |
Normal (18.5–24.9) | 425 | 69.6 | 219 | 73.0 | 206 | 66.2 | |
Overweight & Obese (≥25) | 72 | 11.8 | 33 | 11.0 | 39 | 12.5 | |
Current TB at study enrollment | 31 | 5.1 | 9 | 3.0 | 22 | 7.1 | 0.02 |