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Table 3 Factors associated with treatment outcome among RIF-susceptible and RIF-resistant patients

From: Impact of GeneXpert MTB/RIF® on treatment initiation and outcomes of RIF-resistant and RIF-susceptible TB patients in Vladimir TB dispensary, Russia

 

RIF-susceptible Patients (252)

RIF-resistant Patients (53)

Poor outcome

Successful outcome

OR (95% CI)*

p *

Poor outcome

Successful outcome

OR (95% CI)*

p*

N = 53

N = 199

  

N = 25

N = 28

  

Age

15–24

4

28

0.49 (0.13, 1.56)

0.25

3

2

2.56 (0.29, 27.91)

0.41

25–34

16

55

ref

 

5

9

ref

 

35–44

11

39

0.97 (0.39, 2.33)

0.95

8

7

2.01 (0.44, 9.70)

0.37

45–54

13

44

1.02 (0.43, 2.35)

0.97

6

7

1.52 (0.31, 7.69)

0.61

55–64

8

22

1.25 (0.45, 3.33)

0.66

2

2

1.74 (0.14, 21.3)

0.65

65+

1

11

0.32 (0.01, 2.07)

0.29

1

1

1.73 (0.04, 77.51)

0.75

Sex

Male

45

141

2.31 (1.05, 5.53)

0.04

23

21

3.74 (0.74, 28.83)

0.11

Female

8

58

ref

 

2

7

ref

 

Employment

Retired

10

39

3.01 (1.01, 9.54)

0.05

4

10

1.57 (0.22, 14.97)

0.68

Unemployed

37

89

4.89 (2.03, 13.38)

< 0.01

19

10

7.19 (1.37, 57.69)

0.02

Employed

6

71

ref

 

2

8

ref

 

HIV Positive **

Yes

8

9

3.71 (1.31, 10.4)

0.01

6

0

< 0.01

No

45

189

ref

 

19

27

  

Health Care Worker

Yes

2

4

1.91 (0.24, 11.04)

0.48

0

1

0.52

No

51

195

ref

 

25

27

  

Police Officer

Yes

0

4

0.39

0

1

0.52

No

53

195

ref

 

25

27

  

Contact ***

Yes

13

57

0.84 (0.40, 1.67)

0.63

13

8

3.17 (0.99, 10.68)

0.05

No

38

139

ref

 

10

20

ref

 

Previous TB history

Yes

12

19

2.77 (1.24, 6.16)

<.0001

6

7

0.95 (0.27, 3.32)

0.9

No

41

180

ref

 

19

21

ref

 

Previously Imprisoned#

Yes

19

40

2.19 (1.12, 4.23)

0.02

12

5

4.12 (1.20, 15.7)

0.02

No

34

157

ref

 

13

23

ref

 

Homeless##

Yes

4

2

7.91 (1.37, 63.3)

0.02

2

2

1.13 (0.11, 11.57)

0.91

No

49

196

ref

 

23

26

ref

 

Alcohol

Yes

12

27

1.86 (0.84, 3.96)

0.12

8

8

1.17 (0.35, 3.92)

0.79

No

41

172

ref

 

17

20

ref

 

IDU###

Yes

4

8

1.96 (0.50, 6.78)

0.31

5

1

6.86 (0.87, 175)

0.07

No

49

189

ref

 

19

27

ref

 

Smoke now

Yes

46

146

2.38 (1.05, 6.02)

0.04

23

22

3.07 (0.58, 24.16)

0.20

No

7

53

ref

 

2

6

ref

 

Smoke ever$

Yes

49

162

3.62 (1.17, 15.38)

0.02

25

23

0.03

No

3

36

ref

 

0

5

  

Xpert

Post-Xpert

20

94

0.68 (0.36, 1.26)

0.22

11

15

0.69 (0.23, 2.06)

0.50

Pre-Xpert

33

105

ref

 

14

13

ref

 

Cavity$$

Yes

29

65

2.6 (1.4, 4.8)

0.003

18

15

2.2 (0.7, 7.0)

0.17

No

23

134

ref

 

7

13

ref

 

TB presentation$$$

Pulmonary

47

184

0.96 (0.3, 3.0)

0.9

23

28

0.13

Any EPT

4

15

ref

 

2

0

  

Smear

Pos

37

105

2.1 (1.1, 3.9)

0.03

24

22

6.5 (0.7, 58.7)

0.09

Neg

16

94

ref

 

1

6

ref

 

Any additional res to FLD&

Yes

N/A

N/A

N/A

N/A

23

19

3.6 (0.3, 37.8)

0.3

No

    

1

3

ref

 

Resistance to 4 FLD&&

Yes

N/A

N/A

N/A

N/A

16

11

2.0 (0.6, 6.6)

0.3

No

    

8

11

ref

 

Any SLD&&&

Yes

N/A

N/A

N/A

N/A

8

13

0.4 (0.1, 1.5)

0.08

No

    

16

9

ref

 
  1. * Conditional maximum likelihood estimate odds ratios and corresponding mid-exact p-values** HIV status was missing for 2 patients (1 RIF-susceptible; 1 RIF-resistant)*** Contact info was missing for 7 patients (5 RIF-susceptible; 2 RIF-resistant)# Prison history and smoking history were missing for 2 patients (RIF-susceptible)## Homeless status was missing for 1 patient (RIF-susceptible)### IDU history was missing for 3 patients (2 RIF-susceptible; 1 RIF-resistant)
  2. $ Smoke ever was missing for 2 patients (RIF-susceptible)
  3. $$ Cavity information was missing for 1 patient (RIF-susceptible)
  4. $$$ TB presentation was missing for 2 patients (RIF-susceptible)
  5. & Any additional resistance to first-line drugs (FLD) was missing for 7 patients (RIF-resistant)
  6. && Resistance to 4 FLD was missing for 7 patients (RIF-resistant)
  7. &&& Resistance to any second-line drugs (SLD) was missing for 7 patients (RIF-resistant)