Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda

Table 1 Comparison of characteristics of patients with and without at least one potential drug-drug interaction

	One or more pDDI in study period n = 959	No pDDI in study period n = 115	p value*
Demographics
Age			0.477
17–30	316 (32.9)	42 (36.5)
31–40	403 (42.0)	48 (41.7)
41–50	203 (21.2)	20 (17.4)
51+	37 (3.9)	5 (4.3)
Gender			0.070
Male	560 (58.4)	57 (49.6)
Female	399 (41.6)	58 (50.4)
Baseline diagnostics and investigations
CD4 (cells/mm³)	18 (7–55)	35 (16–209)	0.040
Diagnosis of cryptococcal meningitis			<.001
No	364 (38.0)	105 (91.3)
Yes	595 (62.0)	10 (8.7)
Diagnosis of tuberculosis			0.049
No	852 (88.8)	109 (94.8)
Yes	107 (11.2)	6 (5.2)
Diagnosis of malaria			0.209
No	946 (98.6)	115 (100)
Yes	13 (1.4)	0
GCS on admission			0.003
15	588 (61.4)	54 (47)
< 15	369 (38.6)	61 (53)
CSF QCC (log₁₀CFU/mL)	4.58 (2.9–5.4)	0 (0–6.6)	0.053
In-patient data
Number of administered drugs	7 (5–9)	3 (2–4)	<.001
Days of stay in hospital	16 (11–19)	8 (4.5–13)	<.001

Number of administered drugs, days in hospital, CD4, CSF QCC = median (25th -75th percentile)
Category of age, gender, diagnoses and GCS
CSF Cerebral Spinal Fluid, QCC Quantitative Cryptococcal Culture, CFU Colony Forming Units – for patients presenting with suspected cryptococcal meningitis and for whom CSF culture was collected and quantified (N = 947 with at least one DDI; N = 112 with no DDI)
* t test of means for continuous variables and chi-square for categorical variables with significance at p < .05

ISSN: 1471-2334