Table 4 Factors associated with 12 month estimated glomerular filtration rates in HIV positive adults in Ethiopia. Values are from univariate and multivariate linear regression with coefficient B, 95% confidence interval (CI) and P value

 18–25

–

 26–35

−8.4 (− 12.4; − 4.5)

−5.5 (− 9.5; − 1.4)

0.008⁺

 36–45

− 14.6 (− 19.3; − 9.9)

− 9.7 (− 14.6; − 4.7)

< 0.001⁺

  > 45

−22.6 (− 28.7; − 16.5)

− 15.4 (− 22.1; − 8.7)

< 0.001⁺

 Sex, Female

1.7 (− 1.9; 5.2)

–

–

 Body mass index, kg/m²

−0.2 (− 0.9; 0.4)

–

–

 Fat mass index, kg/m²

−0.3 (− 1.2; 0.5)

–

 Fat free mass index, kg/m²

−0.2 (− 1.2; 0.8)

–

–

 Hypertension, Yes

0.01 (− 6; 6)

–

–

 C-reactive protein, mg/L

−0.01 (− 0.1; 0.07)

–

–

 CD4 count, cells/ul

0.002 (−0.01; 0.02)

–

–

 On tuberculosis treatment, Yes

−1.8 (− 7.5; 3.9)

–

–

 Hepatitis B surface antigen positive, Yes

4.2 (− 5.3; 13.8)

–

–

 Hepatitis C virus antibody Positive, Yes

0.5 (−26.2; 27.3)

–

–

 Viral load, log (copies+ 1/mL)

0.3 (−1.4; 2.1)

–

–

 eGFR, ml/min/1.73 m2

0.3 (0.23; 0.38)

0.2 (0.1; 0.3)

< 0.001⁺

 Change in body mass index, kg/m²

0.1 (−1; 1.2)

–

–

 Change in fat mass index, kg/m²

−0.4 (−1.8; 1)

–

–

 Change in fat free mass index, kg/m²

0.8 (−1; 2.6)

–

–

 Change in CD4 count, cells/ul

0.03 (0.01; 0.05)

0.01 (−0.005; 0.02)

0.18⁺

 Viral load > 1000 copies/ml at 6 months, Yes

−15.1 (−23.4; −6.8)

−9.9 (− 17.2; − 2.5)

0.009⁺

 TDF Treatment

−2.5 (−7; 2)

0.2 (−3.8; 4.2)

0.93*