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Table 5 Comparison of patients with catheter removal receiving long- and short-duration antibiotic in the phase 2 study

From: Microbial epidemiology and risk factors for relapse in gram-negative bacteria catheter-related bloodstream infection with a pilot prospective study in patients with catheter removal receiving short-duration of antibiotic therapy

Characteristics and outcomes Long-duration group (N = 33) Short-duration group (N = 11) p-value
Characteristics
 Age (year) 67 (18–81) 68 (24–81) 0.979
 Gender
  Male 16 (48.5%) 5 (45.5%) 1.000
  Female 17 (51.5%) 6 (54.5%) 1.000
 Charlson comorbidity index (score) 5 (0–12) 4 (0–10) 0.936
 Underlying diseases
  HIV infection 0 (0.0%) 0 (0.0%)
  Cancer 7 (21.2%) 3 (27.3%) 0.692
  Liver disease 1 (3.0%) 1 (9.1%) 0.442
  Renal disease 16 (48.5%) 4 (36.4%) 0.728
  COPD 1 (3.0%) 0 (0.0%) 1.000
  Diabetes mellitus 13 (39.4%) 5 (45.5%) 0.738
  Hematological disease 2 (6.1%) 1 (9.1%) 1.000
  Cardiovascular disease 8 (24.2%) 7 (63.6%) 0.028a
  Trauma 1 (3.0%) 0 (0.0%) 1.000
 Immunocompromised status 6 (18.2%) 2 (18.2%) 1.000
 Microbial etiology
  Monomicrobial 31 (93.9%) 10 (90.9%) 1.000
  Polymicrobial 2 (6.1%) 1 (9.1%) 1.000
 Origin of infection
  Healthcare-associated 9 (27.3%) 1 (9.1%) 0.408
  Nosocomial 24 (72.7%) 10 (90.9%) 0.408
 ICU admission at onset of infection 13 (39.4%) 4 (36.4%) 1.000
 Surgery at present admission 18 (54.5%) 6 (54.5%) 1.000
 Type of catheter
  Tunneled hemodialysis catheter 10 (30.3%) 2 (18.2%) 0.698
  Short-term central venous catheter or arterial catheter 19 (57.6%) 4 (36.4%) 0.303
  Long-term central venous catheter or port 4 (12.1%) 5 (45.5%) 0.030a
 Total duration of therapy (day) 17 (14–30) 7 (7–10) < 0.001a
 Duration of therapy after catheter removal (day) 14 (1–23) 7 (7–7) < 0.001a
Outcome
 Relapse 1 (3.0%) 0 (0.0%) 1.000
 Death 4 (12.1%) 1 (9.1%) 1.000
 Time to next antibiotic use (hour) 357.25 (54.0–444.0) 224.0 (176.0–312.75) 0.400
 Indication of next antibiotic used
  New infectious episode 3 (9.1%) 2 (18.2%) 1.000
  Non-infectious episode 0 (0.0%) 0 (0.0%)
  Relapse 1 (3.0%) 0 (0.0%) 1.000
  Undetermined episode 0 (0.0%) 1 (9.1%) 0.429
  1. ap-value < 0.05
  2. Abbreviations: HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, ICU intensive care unit
  3. Data were presented as frequency (percent) except for age, Charlson comorbidity index, total duration of therapy, duration of therapy after catheter removal and time to next antibiotic use, which were presented as median (minimum-maximum)