Fig. 3

The changes in CD8⁺PD-1⁺ T cells and CD8⁺PD-1⁻ T cells at baseline and post-treatment. a: Representative images of CD8⁺PD-1⁺ T cells and CD8⁺PD-1⁻ T cells on the same slide from sample of case 231,167 evaluated by multiplex immunohistochemical staining. 400× magnification. PID: Patient ID. b-d: The changes in the levels of CD8⁺ T cells, CD8⁺PD-1⁺ T cells, and CD8⁺PD-1⁻ T cells at baseline and post-treatment in the FIER groups (n = 7). e-g: The changes in the levels of CD8⁺ T cells, CD8⁺PD-1⁺ T cells and CD8⁺PD-1⁻ T cells at baseline and post-treatment in the FIENR groups (n = 9)