Table 1 Characteristics of the CHB patients

Age (month, M ± SD)

364.03 ± 92.12

367.03 ± 92.12

370.03 ± 92.12

373.03 ± 92.12

376.03 ± 92.12

Gender (male/female)

24/8

24/8

24/8

24/8

24/8

WBC count (10⁹/L)

5.69 ± 1.48

4.14 ± 1.18

3.64 ± 1.01^**

3.52 ± 1.14^**

3.33 ± 1.13^**

RBC count (10¹²/L)

4.87 ± 0.64

4.83 ± 0.55

4.61 ± 0.64

4.55 ± 0.60^*

4.48 ± 0.63^*

Platelet count (10⁹/L)

190.74 ± 60.21

144.86 ± 51.92^**

122.69 ± 44.02^**

118.42 ± 47.74^**

113.16 ± 45.33^**

ALT, U/L (median)

98.95 (74.8–189.48)

85.85 (68.5–116.33)

66.2 (44.9–118)^**

58.35 (39.05–73.98)^**

46.4 (32.58–56.83) ^**

AST, U/L (median)

57.8 (44.25–83.95)

51.05 (36.4–65.78)

43.9 (35.2–58)^*

36.3 (28.15–45.73)^**

29.8 (23.35–39.05) ^**

TBIL, (umol/L, M ± SD)

18.7 ± 7.61

17.93 ± 9.24

15.04 ± 9.39

14.72 ± 8.41

13.74 ± 7.32^*

DBIL, (umol/L, M ± SD)

5.62 ± 3.7

6.36 ± 4.99

5.32 ± 3.34

5.44 ± 3.16

4.95 ± 2.95

ALB, (g/L, M ± SD)

45.71 ± 4.9

45.53 ± 4.98

45.66 ± 4.7

45.93 ± 4.46

45.97 ± 4.65

HBeAg (median)

864.31 (362.12–1236.09)

456.83 (103.55–1210.75)

395.27 (0.56–996.45)^*

93.77 (0.38–1020.25) ^**

52.86 (0.29–1054.42) ^**

HBeAg positive/negative

32/0

29/3

22/10

19/13

17/15

HBV-DNA (log10) (median)

7.21 (6.7–7.73)

6.74 (4.6–7.8)

6.29 (3.51–7.33)^*

5.4 (2.7–6.35) ^**

3.95 (2.67–5.94) ^**