Table 3 The functions of 14 hub genes
From: Gene network in pulmonary tuberculosis based on bioinformatic analysis
Gene | Scorea | Full name | Functionb |
|---|---|---|---|
CD163 | 12 | Scavenger receptor cysteine-rich type 1 protein M130 | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. |
TLR5 | 11.02941 | Toll-like receptor 5 | Participates in the innate immune response to microbial agents. |
IFIT1 | 10.82353 | Interferon-induced protein with tetratricopeptide repeats 1 | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. |
IFIT2 | 10.82353 | Interferon-induced protein with tetratricopeptide repeats 2 | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2′-O-methylation of the 5′ cap. |
CCR7 | 10.7451 | C-C chemokine receptor type 7 | Receptor for the MIP-3-beta chemokine. Belongs to the G-protein coupled receptor 1 family. |
CXCR3 | 11.2 | C-X-C chemokine receptor type 3 | Isoform 1- Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. |
TLR1 | 10.7451 | Toll-like receptor 1 | Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. |
FCGR2A | 10.63736 | Low affinity immunoglobulin gamma Fc region receptor II-a | Binds to the Fc region of immunoglobulins gamma. |
CD19 | 10.7451 | B-lymphocyte antigen CD19 | Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
IFIH1 | 10.82353 | Interferon-induced helicase C domain-containing protein 1 | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. |
IFI44L | 10.82353 | Interferon-induced protein 44-like | Exhibits a low antiviral activity against hepatitis C virus. |
TLR8 | 10.7451 | Toll-like receptor 8 | Key component of innate and adaptive immunity. |
IFI44 | 10.82353 | Interferon-induced protein 44 | This protein aggregates to form microtubular structures. |
TLR2 | 10.7451 | Toll-like receptor 2 | Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. |