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Table 2 Comparison of clinical manifestations, laboratory and radiologic findings in hospitalized elderly CAP patients with clinical failure and clinical success (n = 3011)

From: Disease burden and prognostic factors for clinical failure in elderly community acquired pneumonia patients

Characteristics

CF(n = 395)

CS(n = 2616)

p value

Clinical features

 Fever

208 (52.7)

1364 (52.1)

0.871

 Cough

327 (82.8)

2368 (90.5)

<0.001

 Chest pain

20 (5.1)

244 (9.3)

0.004

 Wheezing

214 (54.2)

1034 (39.5)

<0.001

 Cyanosis

89 (22.5)

292 (11.2)

<0.001

 Lower extremity edema

98 (24.8)

366 (14.0)

<0.001

 Mental confusion

2016 (26.8)

137 (5.2)

<0.001

 RR > 24beats/min

62 (15.7)

119 (4.5)

<0.001

 HR > 125beats/min

34 (8.6)

40 (1.5)

<0.001

 Hypotension

92 (23.3)

386 (14.8)

<0.001

Laboratory findings

 WBC > 10,000/mm3(n = 2944)

172 (45.1)

762 (29.7)

<0.001

 The rate of NE(n = 2917)

0.8 ± 0.2

0.7 ± 0.1

<0.001

 The rate of L(n = 2890)

0.1 ± 0.1

0.2 ± 0.6

0.007

 NE/L(n = 2889)

14.3 ± 16.5

7.1 ± 9.4

<0.001

 HCT<30%(n = 2874)

86 (22.9)

310 (12.4)

<0.001

 Cr > 123.76 umol/L (n = 2878)

68 (18.2)

217 (8.7)

<0.001

 Glucose> 14 mmol/L(n = 2757)

19 (5.5)

68 (2.8)

0.013

 Na<130 mmol/L(n = 2890)

55 (14.7)

141 (5.6)

<0.001

 BUN> 7 mmol/L(n = 2887)

202 (53.6)

689 (27.5)

<0.001

 PH<7.3(n = 1884)

24 (7.7)

21 (1.3)

<0.001

 PaO2/FiO2<200 mmHg(n = 1857)

70 (23.0)

138 (5.9)

<0.001

 Albumin<25 g/L(n = 2863)

57 (15.7)

154 (6.2)

<0.001

Complications

 Respiratory failure

329 (83.3)

196 (7.5)

<0.001

 Arrhythmia

60 (15.2)

45 (1.7)

<0.001

 Acute heart failure

151 (38.2)

199 (7.6)

<0.001

 Acute myocardial infarction

24 (6.1)

9 (0.3)

<0.001

 Acute liver failure

27 (6.8)

17 (0.6)

<0.001

 Acute renal failure

63 (15.9)

14 (0.5)

<0.001

 Stroke

17 (4.3)

15 (0.6)

<0.001

 DIC

4 (1.0)

1 (0)

0.001

 Gastrointestinal bleeding

47 (11.9)

21 (0.8)

<0.001

 Thromboembolic disease

4 (1.0)

13 (0.5)

0.266

Radiology findings on CT

 Multilobe infiltration (n = 3011)

193 (48.9)

1181 (45.1)

0.178

 Pleural effusion (n = 3011)

146 (37.0)

603 (23.1)

<0.001

  1. Abbreviations: RR Respiratory rate; HR Heart rate; WBC White blood cell; NE Neutrophil; L Lymphocyte; HCT Hematocrit; Cr Creatinine; Na Sodium; BUN Blood urea nitrogen; PaO2/FiO2, Partial arterial oxygen pressure/fraction of inspired oxygen; DIC Disseminated intravascular coagulation; CT Computed tomography