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Table 4 Receiver operating characteristics and predictability of scoring models for positive follow-up blood culture in gram-negative bacteraemia, according to the various cut-off values

From: Predictive scoring models for persistent gram-negative bacteremia that reduce the need for follow-up blood cultures: a retrospective observational cohort study

 

AUC (95% CI)

Cut-off

Sensitivity

Specificity

PPV

NPV

Eradicable source of infectiona

0.861 (0.806–0.916)

−2

88.5%

67.0%

27.7%

97.6%

−1

76.9%

82.1%

38.1%

96.1%

0

46.2%

95.6%

60.0%

92.6%

1

17.3%

99.3%

75%

90.63%

2

3.8%

100%

100%

87.9%

Non-eradicable source of infection

0.792 (0.724–0.861)

−2

83.9%

58.4%

14.4%

97.6%

−1

58.9%

86.9%

27.3%

96.2%

0

39.3%

95.5%

42.3%

95.0%

1

3.6%

100.0%

100.0%

92.5%

  1. AUC Area under the curve, CI Confidence interval, PPV Positive predictive value, NPV Negative predictive value
  2. aGram-negative bacteraemia in which the primary source of infection could be removed, e.g. removal of a central venous catheter or other endovascular device, drainage of a dilated bile duct or hydronephrosis, surgical debridement of skin and soft tissue infection or osteomyelitis, drainage or removal of an intra-abdominal abscess, or drainage of empyema or a lung abscess