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Table 3 Characteristics and outcomes of pregnant women with confirmed drug-resistant tuberculosis (n=8)

From: Tuberculosis clinical presentation and treatment outcomes in pregnancy: a prospective cohort study

Participant

Age

TB Presentation

Baseline DST profile

TB treatment regimen

Treatment Outcome

1

19

• Smear +++ pulmonary TB

• No history of TB

• Cavity seen on CXR

• Cough, cough with blood, cough with phlegm, weight loss, difficulty breathing

MDR (Resistant: INH, RIF, SM)

CS

EMB ETH LEVO PZA

Treatment completed

2

21

• Smear + pulmonary TB

• History of TB

• Cough, cough with phlegm, difficulty breathing, night sweats

MDR

(Resistant: INH, RIF, SM)

CS

EMB ETH LEVO PZA

Lost to follow up

3

29

• Smear – pulmonary TB

• No history of TB

• Cough, cough with blood, cough with phlegm, difficulty breathing, night sweats

Mono-resistant (Resistant SM)

EMB

INH PZA

RIF

Cured

4

30

• Smear – pulmonary TB

• No history of TB

• Cough, cough with blood, cough with phlegm, weight loss, difficulty breathing, night sweats

Mono-resistant (Resistant: EMB)

EMB INH PZA

RIF

Cured

5

34

• Smear ++ pulmonary TB

• History of TB

• Cough, cough with phlegm, weight loss

MDR (Resistant: PZA, INH, EMB, RIF, SM)

CS LEVO PAS PZA

Cured

6

17

• Smear ++ pulmonary TB

• No history of TB

• History of asthma

• Difficulty breathing, night sweats

Mono-resistant (Resistant: SM)

EMB INH LEVO PZA

Cured

7

33

• Smear + pulmonary TB

• History of TB

• Cough, cough with phlegm, weight loss

Mono-resistant (Resistant: RIF)a

EMB INH PZA

RIF

Cured

8

25

• Smear +++ pulmonary TB

• No history of TB

• Cough, cough with blood, cough with phlegm, weight loss

MDR (Resistant: INH, EMB, RIF, SM)

EMB INH PZA

RIF

Treatment completed

  1. Abbreviations: CXR chest x-ray, CS cycloserine, EMB ethambutol, ETH ethionamide, LEVO levofloxacin, PZA pyrazinamide, INH isoniazid, RIF rifampin, SM streptomycin
  2. aRIF resistance was detected on a second drug susceptible test