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Table 9 Decreasing levels of immunocompromised probability (Column 6) to simulate vaccination combined with select parameter combinations from Table 7 (Scenarios 6.1, 6.2, 18.1, 18.2, 22.1, 22.2, 25.1, and 25.2). The eight selected scenarios varied levels of antimicrobial stewardship, ward-room terminal cleaning, and HCW basic compliance with non-quarantined patients while HCW compliance with quarantined patients remained at baseline (60%). (Note that the second decimal place in the scenario number indicates the varying levels of immunocompromised probabilities while XX.X represents the original scenario number from Table 7)

From: Comparing intervention strategies for reducing Clostridioides difficile transmission in acute healthcare settings: an agent-based modeling study

Scenario number

Half-daily antibiotic prob

Targeted antib reduction scenario

Prob of sufficient cleaning

HCW basic compliance

Immuno-compromised prob

Change from median baseline colonizations

Change from baseline median infections

6.1.0

0.27*

2

0.8

0.75

0.10*

-19.25%

-17.19%

6.1.1

0.27*

2

0.8

0.75

0.05

-20.19

-56.43%

6.1.2

0.27*

2

0.8

0.75

0.01

-20.88%

-89.17%

6.2.0

0.27*

2

0.8

1

0.10*

-23.79%

-19.81%

6.2.1

0.27*

2

0.8

1

0.05

-23.55%

-60.44%

6.2.2

0.27*

2

0.8

1

0.01

-23.96%

-91.83%

18.1.0

0.243

3

0.8

0.75

0.10*

-35.16%

-27.12%

18.1.1

0.243

3

0.8

0.75

0.05

-35.55%

-62.96%

18.1.2

0.243

3

0.8

0.75

0.01

-36.27%

-92.90%

18.2.0

0.243

3

0.8

1

0.10*

-38.88%

-26.37%

18.2.1

0.243

3

0.8

1

0.05

-38.85%

-64.25%

18.2.2

0.243

3

0.8

1

0.01

-39.38%

-92.83%

22.1.0

0.216

2

0.2

0.75

0.10*

-29.71%

-20.95%

22.1.1

0.216

2

0.2

0.75

0.05

-30.28%

-60.47%

22.1.2

0.216

2

0.2

0.75

0.01

-31.49%

-92.20%

22.2.0

0.216

2

0.2

1

0.10*

-34.83%

-23.00%

22.2.1

0.216

2

0.2

1

0.05

-35.05%

-61.37%

22.2.2

0.216

2

0.2

1

0.01

-35.52%

-92.23%

25.1.0

0.216

3

0.2

0.75

0.10*

-37.21%

-26.47%

25.1.1

0.216

3

0.2

0.75

0.05

-38.73%

-64.58%

25.1.2

0.216

3

0.2

0.75

0.01

41.87%

-92.38%

25.2.0

0.216

3

0.2

1

0.10*

-41.87%

-29.20%

25.2.1

0.216

3

0.2

1

0.05

-42.34%

-63.98%

25.2.2

0.216

3

0.2

1

0.01

-42.91%

-93.08%

  1. *Baseline value