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Table 1 Clinical characteristics of patients (n = 59)

From: Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia

Characteristics

N (%)a

Age (mean [range]) (years)

60.7 [26–85]

Male

46 (78.0)

MRSAB

36 (61.0%)

Length of total hospital stay (median [IQR]) (d)

27.0 [17.0–46.0]

Duration of bacteremia (median [IQR]) (d)

2.0 [1.0–4.0]

Onset of infection

 Community-associated

11 (18.6)

 Community-onset, healthcare-associated

22 (37.3)

 Hospital-onset

26 (44.1)

In ICU at first positive blood culture

5 (8.5)

CCWI score (median [IQR])

5.0 [2.0–7.0]

Pitt bacteremia score (median [IQR])

1.0 [0.0–3.0]

SOFA score (median [IQR])

4.0 [1.0–8.0]

Severity

 Non-sepsis

9 (15.3)

 Sepsis

35 (59.3)

 Severe sepsis

8 (13.6)

 Septic shock

7 (11.9)

Primary site of infection

 Central venous catheter

15 (25.4)

 Bone and joint

14 (23.7)

 Skin and soft tissue

7 (11.9)

 Lower respiratory tract

6 (10.2)

 Cardiovascular siteb

9 (15.3)

 Unknown

6 (10.2)

 Othersc

2 (3.4)

Treatment

 Appropriate empirical

40 (67.8)

 Appropriate definitived

59 (100)

Time until appropriate antibiotic (mean ± SD) (h)

30.5 ± 26.3

SAB-related 30-day mortality

10 (16.9)

Persistent SAB

14 (23.7%)

Metastatic SAB

6 (10.2)

  1. a unless otherwise specified
  2. b includes infective endocarditis (3) and other endovascular infections (6)
  3. c intraabdominal (1), and urinary tract infection (1)
  4. d treatment with susceptible antibiotics
  5. SD standard deviation, MRSAB methicillin-resistant S. aureus bacteremia, IQR interquartile range, CCWI Charlson’s comorbidity-weighted index, SOFA sequential organ failure assessment