Serial number | Amino acids changes | Phenotypic pyrazinamide susceptibility testing results | ||
---|---|---|---|---|
susceptible | resistant | total | ||
1 | A(−11)G | 0 | 3 | 3 |
2 | Met1Thr | 2 | 2 | 4 |
3 | Leu4Trp | 0 | 1 | 1 |
4 | Ile5Serb | 0 | 1 | 1 |
5 | Val9Alab | 0 | 1 | 1 |
6 | Gln10Pro | 0 | 4 | 4 |
7 | Gln10stop | 1 | 0 | 1 |
8 | Asp12Ala | 0 | 1 | 1 |
9 | Asp12Asn | 2 | 1 | 3 |
10 | Asp12Glu | 0 | 1 | 1 |
11 | His137Argb | 1 | 1 | 2 |
12 | Cys14Glya | 1 | 0 | 1 |
13 | Cys14Tyrb | 0 | 1 | 1 |
14 | Gly17Asp | 0 | 1 | 1 |
15 | Gly17Serb | 0 | 1 | 1 |
16 | Leu27Pro | 0 | 2 | 2 |
17 | Tyr34Ser | 0 | 1 | 1 |
18 | Val44Gly | 0 | 1 | 1 |
19 | Thr160Pro | 0 | 1 | 1 |
20 | Thr47Alaa | 1 | 1 | 2 |
21 | Lys48Arg | 1 | 0 | 1 |
22 | Lys48Glu | 0 | 3 | 3 |
23 | Pro54Leu | 0 | 2 | 2 |
24 | His57Glnb | 0 | 2 | 2 |
25 | Pro62Leu | 0 | 1 | 1 |
26 | Pro62Pro(synonymous)a | 1 | 0 | 1 |
27 | Asp63Tyr/Thr142Lysb | 0 | 1 | 1 |
28 | Ser164Prob | 0 | 1 | 1 |
29 | Ser65Ser(synonymous)a | 1 | 0 | 1 |
30 | Trp68Gly | 0 | 1 | 1 |
31 | Pro69Leu | 1 | 0 | 1 |
32 | His71Pro | 0 | 1 | 1 |
33 | Thr76Pro | 0 | 3 | 3 |
34 | Leu85Pro | 0 | 2 | 2 |
35 | Phe94Ser | 0 | 2 | 2 |
36 | Lys96Arg | 0 | 1 | 1 |
37 | Lys96Metb | 0 | 1 | 1 |
38 | Lys96Thr | 0 | 1 | 1 |
39 | Gly97Ser | 0 | 1 | 1 |
40 | Ser66Leu | 1 | 0 | 1 |
41 | Ala102Pro | 0 | 1 | 1 |
42 | Tyr103Cys | 2 | 0 | 2 |
43 | Tyr103Ser | 1 | 0 | 1 |
44 | Leu116Arg | 0 | 1 | 1 |
45 | Trp119Argb | 0 | 1 | 1 |
46 | Gln122stopb | 0 | 1 | 1 |
47 | Val125Gly | 0 | 1 | 1 |
48 | Val130Alaa | 1 | 0 | 1 |
49 | Val130Met | 1 | 0 | 1 |
50 | Val139Gly | 0 | 1 | 1 |
51 | Gly132Asp | 0 | 3 | 3 |
52 | Ile133Thr | 0 | 1 | 1 |
53 | Asp136Asn | 0 | 1 | 1 |
54 | Asp136Gly | 0 | 1 | 1 |
55 | Cys138Trpb | 0 | 2 | 2 |
56 | Val139Leu | 0 | 2 | 2 |
57 | Arg140Glyb | 0 | 1 | 1 |
58 | Gln141Pro | 0 | 2 | 2 |
59 | Thr100Prob | 0 | 2 | 2 |
60 | Thr142Ala | 0 | 2 | 2 |
61 | Ala146Thrb | 0 | 2 | 2 |
62 | Asn149Val | 0 | 1 | 1 |
63 | Arg154Trpb | 0 | 1 | 1 |
64 | Val155Met | 1 | 0 | 1 |
65 | Val157Glyb | 0 | 1 | 1 |
66 | Thr142Met | 0 | 1 | 1 |
67 | Ala161Glyb | 0 | 1 | 1 |
68 | Gly162Val | 0 | 1 | 1 |
69 | Ala171Vala | 2 | 0 | 2 |
70 | Leu172Prob | 0 | 1 | 1 |
71 | Glu173Glu(synonymous)a | 1 | 0 | 1 |
72 | Glu174Glyb | 0 | 1 | 1 |
73 | Met175Ile | 0 | 2 | 2 |
74 | Met175Val | 0 | 2 | 2 |
75 | Leu182Serb | 0 | 1 | 1 |
76 | Frameshiftb | 1 | 11 | 12 |
– | Wild type | 169 | 35 | 204 |
– | Total | 192 | 132 | 324 |