The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

Table 2 Dosage advice options for intervention

Dosage adjustment	Dose recommendations
Dose increase	Increase dose administration frequency by 25–50%
Dose increase	Increase dose by 25–50% with same dosing frequency
Dose reduction	Decrease dose administration frequency
	Decrease dose by 25–50% with same dosing frequency
	Withhold administration for 1 day

ISSN: 1471-2334