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Table 2 Cumulative fraction of responses (CFR) against 110 Staphylococcus aureus, including MRSA, from bloodstream infections

From: Pharmacodynamic comparison of different antimicrobial regimens against Staphylococcus aureus bloodstream infections with elevated vancomycin minimum inhibitory concentration

Antimicrobial

Regimen

CFR

Sensitivity Analysis

Ceftaroline

600 mg q12h

98%

96–99%

Daptomycin

10 mg/kg q24h

92%

21–100%

Teicoplanin

400 mg q12h

86%

44–78%

Daptomycin

6 mg/kg q24h

79%

3–99%

Linezolid-80a

600 mg q12h

77%

51–94%

Vancomycin

1000 mg q8h

76%

71–77%

Teicoplanin

three 400 mg loading doses q12h followed by 400 mg q24h

65%

8–29%

Linezolid-100a

600 mg q12h

64%

34–87%

Vancomycin

1000 mg q12h

62%

40–62%

  1. a: MIC endpoint values for linezolid were read at the first well where the trailing begins without regard for pinpoint trailing, as CLSI M100-S26 instructions, being designated as linezolid-80; and at 100% inhibition of growth, being designated as linezolid-100