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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Different macrophage polarization between drug-susceptible and multidrug-resistant pulmonary tuberculosis

Fig. 1

The distribution and correlation of the M1-like and M2-like polarization rates between MDR-TB/XDR-TB and DS-TB. a Scatterplot of the M1-like and M2-like polarization rates for each group. In the DS-TB group, the M1-like and M2-like polarization rates had a moderate positive correlation. In the MDR-TB/XDR-TB group, the M1-like and M2-like polarization rates had a moderate negative correlation. ‘r’ is the partial correlation coefficient adjusted by age. b The median values of M1-like and M2-like polarization rates were obtained, and 83.3% of the DS-TB group were distributed below the median value of the M2-like polarization rate. c The confocal microscopy image (400x field) showed a distinct polarization difference in each quadrant according to the distribution of the M1-like and M2-like polarization rates. All images were obtained with laser excitation at 488 and 594 nm. The iNOS and arginase-1 stains were quantified as the percentage in CD68-positive alveolar macrophages. The average number of iNOS+ or Arginase-1+ cells / CD68+ cells was quantified for each section using ImageJ software (NIH). DS-TB = drug-susceptible tuberculosis; MDR-TB = multidrug-resistant tuberculosis; XDR-TB = extensively drug-resistant tuberculosis; Arg1 = Arginase-1

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