Natural polymorphisms in HIV-1 CRF01_AE strain and profile of acquired drug resistance mutations in a long-term combination treatment cohort in northeastern China

Table 2 Co-variations of conditional selection pressure (cKa/Ks)

Mut1	Mut2	cKa/Ks	LOD	Mut1	Mut2	cKa/Ks	LOD
Y181C	G190S	22.86	Inf	K65R	Y115F	2	3.93
G190S	K65R	18	10.69	K65R	V179 T	2	Inf
G190S	Y181C	17	10.06	K65R	V179E	2	Inf
Y181C	L228R	6	4.09	K65R	L228R	2	3.46
V179D	V106 M	5	Inf	M184 V	Y115F	2	3.93
K65R	G190S	3.97	Inf	M184 V	V179D	2	9.16
K65R	Y181C	3.5	7.73	Y181C	V179 T	2	Inf
V75 L	G190S	3.24	Inf	G190S	Y115F	1.5	2.62
M184 V	V106 M	3	Inf	G190S	V179D	1.5	2.62
G190S	V75 L	2.5	4.03	Y181C	K65R	1.5	8.8
L228R	G190S	2.25	Inf	G190S	L228R	1.33	3.74
G190S	V179 T	2	Inf	M184 V	V75 L	1.25	4.03
G190S	V179E	2	Inf	K65R	V106 M	1.2	Inf
K65R	V75 L	2	5.04	Y115F	G190S	1.05	Inf

Boldface mutations have no annotation in the Stanford HIVdb algorithm. Inf: Infinity. Mut 1/2: mutation 1/2. Because the co-variation based on conditional selection pressure is directional, mutation 1 is the dominant mutation and mutation 2 is the affected mutation

ISSN: 1471-2334