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Table 4 Antimicrobial activity against resistant respiratory Pseudomonas aeruginosa isolates by subset (ATLAS 2016–2018)

From: In vitro antimicrobial susceptibility of clinical respiratory isolates to ceftazidime-avibactam and comparators (2016–2018)

Organism

Antimicrobial

MIC (mg/L)

%S + %Ia

%R

MIC90

Range

P. aeruginosa,

MDR (n = 1281)

Piperacillin-tazobactam

≥256

≤0.25–≥256

8.7

91.3

Aztreonam

128

0.12–≥256

36.5

63.5

Ceftazidime

≥256

0.06–≥256

19.1

80.9

Ceftazidime-avibactam

64

≤0.015–≥256

62.9

37.1

Cefepime

32

0.5–≥64

19.1

80.9

Imipenem

≥16

≤0.03–≥16

17.1

82.9

Meropenem

≥32

≤0.06–≥32

38.6

61.4

Levofloxacin

≥16

≤0.03–≥16

9.6

90.4

Colistin

1

≤0.06–≥16

99.5

0.5

Amikacin

64

≤0.25–≥128

61.3

38.7

P. aeruginosa,

carbapenemase positive/

MBL-negative (n = 53)

Piperacillin-tazobactam

≥256

16–≥256

3.8

96.2

Aztreonam

≥256

2–≥256

28.3

71.7

Ceftazidime

≥256

4–≥256

5.7

94.3

Ceftazidime-avibactam

32

1–≥256

71.7

28.3

Cefepime

≥64

4–≥64

15.1

84.9

Imipenem

≥16

8–≥16

0.0

100

Meropenem

≥32

8–≥32

3.8

96.2

Levofloxacin

≥16

0.5–≥16

5.7

94.3

Colistin

1

0.25–4

98.1

1.9

Amikacin

64

2–≥128

30.2

69.8

P. aeruginosa,

MBL-positive (n = 251)b

Piperacillin-tazobactam

≥256

4–≥256

5.6

94.4

Aztreonam

64

0.25–≥256

56.6

43.4

Ceftazidime

≥256

8–≥256

1.6

98.4

Ceftazidime-avibactam

≥256

2–≥256

2.8

97.2

Cefepime

≥64

8–≥64

4.4

95.6

Imipenem

≥16

4–≥16

0.8

99.2

Meropenem

≥32

4–≥32

3.2

96.8

Levofloxacin

≥16

0.5–≥16

1.6

98.4

Colistin

1

0.25–2

100

0.0

Amikacin

≥128

2–≥128

19.1

80.9

  1. MIC minimum inhibitory concentration; MIC90 MIC required to inhibit the growth of 90% of isolates; %S percent susceptible, standard dosing regimen; %I percent susceptible, increased exposure; %R percent resistant; MDR multidrug-resistant; MBL metallo-β-lactamase
  2. aIncludes all isolates not in the resistant category for all antimicrobial agents
  3. bIsolates in this subset are carbapenemase-positive and MBL-positive