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Table 2 Compliance with the 2009 Belarusian national gonorrhoea guideline [45] in Minsk (749 patients, 2013–2018) and Mogilev (903 patients, 2010–2019), Belarus

From: Antimicrobial resistance in Neisseria gonorrhoeae isolates and gonorrhoea treatment in the Republic of Belarus, Eastern Europe, 2009–2019

Prescribed antimicrobials

Minsk

No. (%, 95 CI)

Mogilev

No. (%, 95 CI)

Recommended first-line treatment [45]

 CRO 1 g × 1 IM (uncomplicated gonorrhoea) or CRO 1 g × 1 IM or IV every 24 h, 7 days (complicated gonorrhoea)a

354 (47.3, 43.7–51.0)

508 (56.3, 53.0–59.6)

Alternative treatment [45]

 CFM 400 mg × 1 orally

5 (0.7, 0.2–1.6)

0

 OFX 400 mg × 1 orally

26 (3.5, 2.3–5.1)

123 (13.6, 11.4–16.0)

Non-compliant treatment

 Non-compliant antimicrobials or doses given, generally higher than recommended

364 (48.6, 45.0–52.3)b

272 (30.1, 27.1–33.2)c

  1. No. Number, CI Confidence interval, CRO Ceftriaxone, IM Intramuscularly, IV Intravenously, CFM Cefixime, OFX Ofloxacin
  2. aFrequently, additional antimicrobials were given to treat other non-viral STIs, which had been confirmed or not excluded by appropriate laboratory diagnostics. These included doxycycline, other tetracyclines, different macrolides, fluoroquinolones, oral cephalosporins, penicillins, and nitroimidazoles
  3. bMore than 1 g of ceftriaxone was quite often given; approximately 10% of the patients received benzylpenicillin, about 5% a tetracycline/macrolide regimen, and one (0.1%) patient was given rifampicin
  4. cMore than 1 g of ceftriaxone was somewhat frequently given. A benzylpenicillin regimen was rarely given, and for a few patients, > 400 mg ofloxacin or a tetracycline/macrolide regimen was administered