Fig. 5

Changes of serum creatinine within individuals over time in chronic HBV patients with TDF treatment vs. without treatment. (A) Variation of serum creatinine levels within individuals over time; (B) Stratifications of serum creatinine elevation levels within individuals over time. In panel A, variation in the x-axis is calculated as the standard deviation of creatinine values of an patients during the follow-up period, y-axis is the probability of patients having a corresponding variation. In panel B, red sections represent the percentage of patients had AKI events, which is defined as an elevation of serum creatinine of ≥ 26.5 μmol/l or ≥ 1.5 times compared to previous time point. AKI, acute kidney injury. TDF, Tenofovir disoproxil fumarate