Table 1 Baseline characteristics of the study population
Parameters | TAF 25 mg | TDF 300 mg | ETV 0.5 mg | P value |
|---|---|---|---|---|
(n = 10) | (n = 10) | (n = 20) | ||
Age (years) | 40.56 ± 11.18 | 41.00 ± 12.64 | 39.72 ± 9.13 | 0.901 |
Male, n (%) | 10 (100) | 10 (100) | 20 (100) | 1.0 |
Liver cirrhosis | 8 (80) | 7 (70) | 13 (65) | 0.901 |
ALT (U/L) | 351.10 (308.72) | 203.67 (173.61) | 385.85 (519.33) | 0.588 |
AST (U/L) | 263.78 (242.47) | 156.89 (84.39) | 382.61 (397.06) | 0.707 |
TBIL (μmol/L) | 362.93 (178.62) | 321.10 (127.87) | 240.44 (144.35) | 0.174 |
Albumin (g/L) | 31.32 (3.71) | 30.90 (4.38) | 32.23 (4.19) | 0.905 |
Urea (mmol/L) | 5.71 (3.09) | 5.74 (2.70) | 5.86 (3.23) | 0.948 |
Creatinine (μmol/L) | 77.22 (34.20) | 66.22 (22.08) | 66.00 (24.27) | 0.458 |
eGFR (mL/min/1.73m2) | 112.76 (41.47) | 150.23 (30.12) | 112.34 (68.85) | 0.274 |
INR | 1.71 (0.32) | 2.08 (0.87) | 2.13 (0.63) | 0.179 |
WBC (× 109/L) | 6.22 (1.82) | 7.28 (3.48) | 6.91 (3.54) | 0.819 |
PLT (×109/L) | 115.11 (60.48) | 97.44 (113.02) | 98.33 (63.09) | 0.168 |
Serum sodium, mmol/L | 137.11 (2.32) | 135.11 (4.96) | 135.16 (7.06) | 0.784 |
HbeAg positive | 8 (80) | 8 (80) | 15 (75) | 0.931 |
LogHBV DNA (log IU/mL) | 4.80 (1.93) | 5.81 (1.87) | 5.13 (1.89) | 0.458 |
MELD score | 21.56 (5.66) | 21.33 (7.28) | 20.50 (5.40) | 0.943 |
CTP score | 10.22 (1.44) | 10.78 (1.64) | 10.44 (1.56) | 0.151 |
CTP class(B/C) | 3/7 | 1/9 | 1/19 | 0.202 |
NUC-naïve | 7 (70) | 2 (20) | 15 (75) | 0.019 |
Follow-up (wk) | 68.50 (48–92) | 64.50 (51–95) | 69.00 (50–95) | 0.938 |