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Table 1 The distribution of serotypes and clinical characteristics in patients with invasive pneumococcal disease (IPD) caused by the 24 most prevalent serotypes in Southwest Sweden between 2009 and 2015

From: Invasive pneumococcal disease in persons with predisposing factors is dominated by non-vaccine serotypes in Southwest Sweden

  

Clinical characteristics

Serotype

Number of strains, n (%)

Median age (y)

Predisposing factorsa, n (%)

Meningitis#, n (%)

Pneumonia#, n (%)

Bacteremia with unknown focus, n (%)

Other manifestationb, n (%)

Admitted to the intensive care unit, n (%)

Case fatality ratec, n (%)

22F

135 (10)

70

112 (83)

10 (7)

92 (68)

17 (13)

16 (12)*

30 (22)

17 (13)

3

128 (10)

68

99 (77)

15 (12)

100 (78)

8 (6)*

5 (4)

46 (36)***

23 (18)

7F

99 (8)

60***

65 (66)***

4 (4)

84 (85)**

5 (5)**

7 (7)

17 (17)

4 (4)**

9 V

68 (5)

65

54 (79)

2 (3)

59 (87)**

4 (6)

3 (4)

16 (24)

4 (6)

14

67 (5)

75

53 (79)

4 (6)

60 (90)***

2 (3)**

1 (2)

16 (24)

9 (13)

33F

59 (5)

67

49 (83)

7 (12)

35 (59)*

13 (22)*

4 (7)

12 (20)

5 (8)

4

57 (4)

64

47 (83)

2 (4)

49 (86)*

4 (7)

3 (5)

20 (36)*

4 (7)

19A

53 (4)

75*

43 (81)

3 (6)

39 (74)

9 (17)

2 (4)

16 (30)

10 (19)

11A

49 (4)

70

45 (92)*

4 (8)

35 (71)

7 (14)

4 (8)

14 (29)

10 (20)

9 N

47 (4)

71

42 (89)

1 (2)

38 (81)

5 (11)

4 (9)

7 (15)

4 (9)

8

43 (3)

66

35 (81)

2 (5)

34 (79)

4 (9)

3 (7)

4 (9)*

2 (5)

6A

42 (3)

74

33 (79)

2 (5)

29 (69)

9 (21)

2 (5)

11 (26)

6 (14)

23F

36 (3)

70

29 (81)

1 (3)

23 (64)

5 (14)

6 (17)*

4 (11)

2 (6)

23A

35 (3)

75

30 (86)

5 (14)

20 (57)

6 (17)

4 (11)

6 (17)

5 (14)

6B

34 (3)

75

29 (85)

4 (12)

27 (79)

3 (9)

0 (0)

6 (18)

7 (21)

1

32 (2)

49***

18 (56)**

1 (3)

30 (94)**

1 (3)

0 (0)

2 (6)*

1 (3)

18C

27 (2)

66

20 (74)

5 (19)

17 (63)

3 (11)

2 (7)

6 (22)

2 (7)

35F

26 (2)

73

24 (92)

1 (4)

18 (69)

7 (27)

0 (0)

4 (15)

4 (15)

23B

26 (2)

75

19 (73)

4 (15)

8 (31)***

10 (39)**

4 (15)

9 (35)

3 (12)

6C

25 (2)

82**

20 (80)

0 (0)

20 (80)

4 (16)

1 (4)

5 (20)

4 (16)

19F

25 (2)

68

20 (80)

3 (12)

16 (64)

5 (20)

1 (4)

7 (28)

5 (20)

12F

24 (2)

70

17 (71)

3 (13)

14 (58)

3 (13)

4 (17)

6 (25)

3 (13)

10A

24 (2)

72

23 (96)

3 (13)

12 (50)*

6 (25)

3 (13)

6 (25)

6 (25)

15C

20 (2)

68

15 (75)

5 (25)*

8 (40)**

7 (35)*

0 (0)

5 (25)

3 (15)

Other d

123 (9)

71

110 (89)

12 (10)

76 (62)

26 (21)

11 (9)

30 (24)

22 (18)

Total

1304

69

1051 (81)

102 (8)

943 (72)

173 (13)

90 (7)

302(23)

165 (13)

  1. * p < 0.05, ** p < 0.01, *** p < 0.001; versus total
  2. # There were five episodes of both pneumonia and meningitis. These were included in the analysis of each of the manifestations
  3. a Smoking, cardiovascular disease, malignancy, pulmonary disease, diabetes mellitus, immunosuppressive treatment, substance abuse, autoimmunity, liver disease, immune deficiency, renal disease and asplenia
  4. bAbscess, appendicitis, bronchitis, cholangitis, endocarditis, epidural abscess, epiglottitis, mastoiditis, osteitis, otitis media, pharyngitis, peritonitis, prosthetic joint infection, septic arthritis, skin and soft tissue infection, sinusitis and uteritis
  5. cDeath within 30 days of positive culture for pneumococci
  6. dIncluding serotype 15B (n = 19), 35B (n = 17), 16F (n = 13), 31 (n = 11), 15A (n = 11), 38 (n = 10), 24F (n = 9), 20 (n = 7), 17F (n = 6), 10B (n = 3), 34 (n = 3), Not typable (n = 3), 18A (n = 2), 7C (n = 2), 35A (n = 1), 9A (n = 1), 23 (n = 1), 9 (n = 1), 21 (n = 1), 11 (n = 1) and 5 (n = 1)
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BMC Infectious Diseases

ISSN: 1471-2334

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