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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report

Fig. 2

Demonstration of BoDV-1 antigen, BoDV-1 genomic RNA and viral mRNA. A BoDV-1 phosphoprotein (P) is demonstrated as intranuclear inclusions of neurons (arrows) and astrocytes (arrowheads) in midbrain. Diaminobenzidine immunostain with hematoxylin counterstain with 200-fold magnification. B Genomic BoDV-1 RNA (N gene) is present only in nuclei of brain cells. Midbrain, 100-fold magnification. C The respective viral mRNA (N gene) is also predominantly located in the nuclei of brain cells, with few cells also displaying cytoplasmic signals (arrows). Midbrain, 100-fold magnification

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