Regional variation in the potentially inappropriate first-line use of fluoroquinolones in Canada as a key to antibiotic stewardship? A drug utilization review study

St-Jean, Audray; Chateau, Dan; Dahl, Matthew; Ernst, Pierre; Daneman, Nick; Sketris, Ingrid S.; Zhang, Jianguo; Marra, Fawziah; Quail, Jacqueline; Bugden, Shawn

doi:10.1186/s12879-021-06467-z

Table 1 Top 3 most common antibiotic dispensations associated with uncomplicated UTI, ABS and AECOPD events

From: Regional variation in the potentially inappropriate first-line use of fluoroquinolones in Canada as a key to antibiotic stewardship? A drug utilization review study

Province	Year	Antibiotic dispensations
Province	Year	1	2	3
Uncomplicated UTI
Alberta	2009	Ciprofloxacin	Nitrofurantoin	tmp/smx
Alberta	2015	Nitrofurantoin	Ciprofloxacin	tmp/smx
British Columbia	2005	Ciprofloxacin	tmp/smx	nitrofurantoin
British Columbia	2015	Nitrofurantoin	Ciprofloxacin	tmp/smx
Manitoba	2005	tmp/smx	Ciprofloxacin	Nitrofurantoin
Manitoba	2014	Ciprofloxacin	tmp/smx	Nitrofurantoin
Nova Scotia	2005	tmp/smx	Nitrofurantoin	Ciprofloxacin
Nova Scotia	2015	Nitrofurantoin	tmp/smx	Ciprofloxacin
Ontario	2005	Nitrofurantoin	Norfloxacin	tmp/smx
Ontario	2015	Nitrofurantoin	ciprofloxacin	tmp/smx
Saskatchewan	2008	Nitrofurantoin	tmp/smx	Ciprofloxacin
Saskatchewan	2015	Nitrofurantoin	tmp/smx	Ciprofloxacin
ABS
Alberta	2009	Amoxicillin	Clarithromycin	Azithromycin
Alberta	2015	Amoxicillin	Clarithromycin	amox/clav
British Columbia	2005	Amoxicillin	Clarithromycin	Azithromycin
British Columbia	2015	Amoxicillin	Clarithromycin	amox/clav
Manitoba	2005	Amoxicillin	Azithromycin	Clarithromycin
Manitoba	2014	Amoxicillin	Azithromycin	Clarithromycin
Nova Scotia	2005	Amoxicillin	Cefuroxime	Azithromycin
Nova Scotia	2015	Amoxicillin	amox/clav	Cefuroxime
Ontario	2005	Amoxicillin	Clarithromycin	Azithromycin
Ontario	2016	Amoxicillin	Azithromycin	amox/clav
Saskatchewan	2008	Amoxicillin	Azithromycin	Cephalexin
Saskatchewan	2015	Amoxicillin	Azithromycin	Clarithromycin
AECOPD
Alberta	2009	Clarithromycin	Levofloxacin	Azithromycin
Alberta	2015	Levofloxacin	Azithromycin	Doxycycline
British Columbia	2005	Clarithromycin	Azithromycin	Amoxicillin
British Columbia	2015	Clarithromycin	Doxycycline	Amoxicillin
Manitoba	2005	Amoxicillin	Azithromycin	Clarithromycin
Manitoba	2014	Azithromycin	Amoxicillin	Levofloxacin
Nova Scotia	2005	Azithromycin	Amoxicillin	Cefuroxime
Nova Scotia	2015	Doxycycline	Amoxicillin	Clarithromycin
Ontario	2005	Clarithromycin	Azithromycin	Levofloxacin
Ontario	2017	Azithromycin	Amoxicillin	amox/clav
Saskatchewan	2008	Doxycycline	Azithromycin	Amoxicillin
Saskatchewan	2015	Azithromycin	Doxycycline	Amoxicillin

Data are presented by province at the start and end of study period. Fluoroquinolone antibiotics are in bold
ABS acute bacterial sinusitis, AECOPD acute exacerbation of chronic obstructive pulmonary disease, amox/clav amoxicillin/clavulanic acid, tmp/smx trimethoprim/sulfamethoxazole, UTI urinary tract infection

Back to article page

ISSN: 1471-2334

Contact us

Submission enquiries: bmcinfectiousdiseases@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Infectious Diseases

Contact us