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Table 2 Univariable and multivariable analysis of TST and IGRA positivity

From: Tuberculosis infection screening in children with close contact: a hospital-based study

 

IGRA positivity (≥ 8 spots)

TST(≥ 10 mm)

 

n/N (%)

p for X2 test#

Adjusted OR*(95%CI)

n/N (%)

p for X2 test#

Adjusted OR*(95%CI)

Sex

 

0.32

  

0.98

 

 Male

35/3748 (0.9%)

 

Reference

115/3748 (3.1%)

 

Reference

 Female

17/2454 (0.7%)

 

0.7 (0.4–1.2)

76/2454 (3.1%)

 

1.0 (0.8–1.3)

Age(years)

 

0.006

  

0.049

 

 0–2 y

12/2327 (0.5%)

 

Reference*

63/2327 (2.7%)

 

Reference*

 3–4 y

4/924 (0.4%)

 

0.8 (0.3–2.2)*

21/924 (2.3%)

 

0.8 (0.5–1.2)

 5–18

36/2951 (1.2%)

 

2.5 (1.4–4.4)*

107/2951 (3.6%)

 

1.3 (1.1–1.8)*

District

 

 < 0.001

  

 < 0.001

 

 Eastern

28/4662 (0.6%)

 

Reference*

109/4662 (2.3%)

 

Reference*

 Middle

10/1042 (1.0%)

 

2.1 (1.1–3.7)*

44/1042 (4.2%)

 

2.0 (1.5–2.6)*

 Western

14/498 (2.8%)

 

3.2 (1.7–6.1)*

38/498 (7.6%)

 

3.2 (2.4–4.4)*

Resident place

 

0.78

  

0.82

 

 City

27/3376 (0.8%)

 

Reference

105/3376 (3.1%)

 

Reference

 Rural

25/2826 (0.9%)

 

1.5 (0.9–2.6)

86/2826 (3.0%)

 

1.0 (0.8–1.3)

BCG vaccination history

 

0.98

  

0.07

 

 Yes

51/6086 (0.8%)

 

186/6086 (3.1%)

 

Reference

 No

1/116 (0.9%)

 

5/116 (4.3%)

 

1.2 (0.7–2.1)

Presence of BCG scar

 

0.79

  

0.77

 

 Yes

49/5895 (0.8%)

 

Reference

183/5895 (3.1%)

 

Reference

 No

3/307 (1.0%)

 

2.0 (0.8–5.0)

8/307 (2.6%)

 

0.9 (0.5–1.6)

Exposure level

 

 < 0.001

  

 < 0.001

 

 No reported contact risk

41/5833 (0.7%)

 

Reference*

151/5833 (2.6%)

 

Reference*

 Non-household contact risk

6/274 (2.2%)

 

1.5 (0.6–3.6)*

23/274 (8.4%)

 

2.7 (1.9–3.9)*

 Household contact risk

5/95 (5.3%)

 

6.1 (2.7–13.9)*

17/95 (17.9%)

 

6.9 (4.5–10.7)*

  1. Data are n/N (%),unless otherwise indicated. n/N (%) is number positive /number with test results (proportion positive)
  2. BCG Bacille Calmette Guerin, IGRA interferon-gamma release assay, TST tuberculin skin test, OR odd ratio, CI confidence interval
  3. #: Univariable analysis; *: multivariable analysis, controlling for variables with p < 0.05 in univariable analysis. p values from the multivariable analysis for IGRA positivity was 0.02,0.005, 0.001 for age, district and exposure level respectively, for TST positivity was 0.13, < 0.001, < 0.001 for age, district and exposure level respectively