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Table 2 Trends of the pooled sero-epidemiology of TTIs among blood donors in Ethiopia (1986–2018)

From: Sero-epidemiology and associated factors of HIV, HBV, HCV and syphilis among blood donors in Ethiopia: a systematic review and meta-analysis

The trend of pooled sero-prevalence of HIV among blood donors in Ethiopia (1989–2018)

Study year (based on mid-term year)

Number of included studies

Total No. of HIV sero-reactive case

Total No. of Population

Pooled prevalence of HIV %(95% CI)

Heterogeneity

Meta-regression (effect of year on HIV prevalence)

I2 %

P-value

Coefficient(95% CI)

P-value

Before 2000

5

1994

20,103

8.84 (5.96, 17.73)

97.7

< 0.001

− 0.089 (− 0.133, − 0.045)

< 0.001

2000–2004

3

95

4313

3.27 (1.02, 5.53)

88.5

< 0.001

2005–2009

3

296

9291

4.55 (1.67, 7.44)

98.6

< 0.001

2010–2014

11

4197

251,971

1.70 (1.14, 2.26)

99.3

< 0.001

2015–2018

12

546

69,348

1.20 (0.87, 1.53)

94.9

< 0.001

Total

34

7128

355,026

2.83 (2.43, 3.23)

99.2

< 0.001

The trend of pooled sero-prevalence of HBV among blood donors in Ethiopia (1986–2018)

Study year (based on mid-term year

Number of included studies

Total No. of HBV sero-reactive case

Total No. of Population

Pooled prevalence of HBV % (95% CI)

Heterogeneity

Meta-regression (effect of year on HBV prevalence)

I2 %

P-value

Coefficient (95% CI)

P-value

Before 2000

3

173

1415

12.03 (9.72, 14.34)

46.2

0.156

− 0.029 (− 0.078, 0.02)

0.25

2000–2004

2

86

1200

7.10 (5.14, 9.05)

44.6

0.179

2005–2009

5

645

14,985

6.72 (4.03, 9.40)

98.7

< 0.001

2010–2014

13

14,652

310,478

4.76 (4.05, 5.47)

98.6

< 0.001

2015–2018

13

2240

63,261

4.30 (3.35, 5.24)

96.8

< 0.001

Total

36

17,796

391,339

5.20 (4.64, 5.77)

98.4

< 0.001

The trend of pooled sero-prevalence of HIV among blood donors in Ethiopia (1991–2018)

Study year (based on mid-term year

Number of included studies

Total No. of HCV sero-reactive case

Total No. of Population

Pooled prevalence of HCV % (95% CI)

Heterogeneity

Meta-regression (effect of year on HCV prevalence)

I2 %

P-value

Coefficient (95% CI)

P-value

Before 2000

2

10

720

1.40 (0.54, 2.26)

0.0

1

− 0.041 (− 0.093, 0.01)

0.114

2000–2004

2

45

1200

3.69 (− 0.36, 7.74)

93.0

< 0.001

2005–2009

4

137

10,136

1.86 (0.81, 2.90)

95.2

< 0.001

2010–2014

12

3182

306,321

0.71 (0.41, 1.00)

98.7

< 0.001

2015–2018

11

453

62,499

0.83 (0.55, 1.11)

91.2

< 0.001

Total

31

3827

380,876

0.93 (0.73, 1.13)

97.3

< 0.001

The trend of pooled sero-prevalence of Syphilis among blood donors in Ethiopia (1989–2018)

Study year (based on mid-term year

Number of included studies

Total No. of Syphilis sero-reactive case

Total No. of Population

Pooled prevalence of Syphilis % (95% CI)

Heterogeneity

Meta-regression (effect of year on Syphilis prevalence)

I2

P-value

Coefficient (95% CI)

P-value

Before 2000

3

1334

23,893

8.39 (3.71, 13.08)

98.8%

 < 0.001

− 0.085 (− 0.156, − 0.015)

0.021

2000–2004

–

–

–

–

–

–

2005–2009

4

113

13,446

0.83 (0.06, 1.59)

96.2%

 < 0.001

2010–2014

8

413

227,743

0.50 (0.29, 0.71)

97.3%

 < 0.001

2015–2018

8

614

55,648

1.04 (0.67, 1.40)

90.8%

 < 0.001

Total

23

2474

320,730

1.50 (1.20, 1.80)

99.0%

 < 0.001

  1. – represents that the given characteristic is not reported, CI confidence interval, HBV hepatitis B virus, HCV hepatitis C virus, HIV human immunodeficiency virus, TTIs transfusion transmissible infections