Table 7 Accuracy of six clinical algorithms for the diagnosis of neuritis in leprosy patients with neural pain (n = 124)
From: Clinical prediction rules for the diagnosis of neuritis in leprosy
Clinical algorithms | Se % (95% CI) | Sp % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | PLR % (95% CI) | NLR % (95% CI) | DOR (95% CI) |
|---|---|---|---|---|---|---|---|
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND movement as worsening pain factor AND spontaneously-declared triggering of pain by palpation | 20.00 (8.07–41.60) | 97.12 (91.86–99.01) | 57.1 (26.02–83.48) | 86.3 (83.35–88.84) | 6.93 (1.68–28.64) | 0.82 (0.66–1.03) | 8.42 (1.72–41.16) |
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND movement as worsening pain factor AND triggering of pain by palpation | 35.00 (18.12–56.71) | 94.23 (87.98–97.33) | 53.8 (31.06–75.13) | 88.30 (84.42–91.30) | 6.07 (2.28–16.16) | 0.69 (0.50–0.95) | 8.80 (2.56–30.22) |
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND spontaneously-declared triggering of pain by palpation | 20.00 (8.07–41.60) | 91.35 (8.37–95.38) | 30.80 (13.61–55.63) | 85.60 (82.41–88.27) | 2.31 (0.79–6.78) | 0.88 (0.70–1.10) | 2.64 (0.72–9.60) |
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND triggering of pain by palpation | 40.0 (21.88–61.34) | 86.54 (78.66–91.81) | 36.4 (21.83–53.91) | 88.20 (83.83–91.56) | 2.97 (1.44–6.13) | 0.69 (0.48–1.0) | 4.29 (1.49–12.33) |
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND physical exertion and movement as worsening pain factors AND spontaneously-declared triggering of pain by palpation | 20.00 (8.07–41.60) | 95.19 (89.24–97.93) | 44.4 (19.87–72.08) | 86.1 (83.05–88.65) | 4.16 (1.22–14.16) | 0.84 (0.67–1.05) | 4,95 (1.20–20.42) |
Pain onset < 90 days OR pain with neurological symptoms ≤ 30 days AND physical exertion and movement as worsening pain factors AND triggering of pain by palpation | 35.0 (18.12–56.71) | 91.35 (84.37–95.38) | 43.7 (25.01–64.46) | 88.0 (83.98–91.06) | 4.04 (1.70–9.60) | 0.71 (0.51–0.99) | 5.68 (1.81–17.86) |