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Table 1. Clinical manifestations and characteristics of auxiliary examinations for 5 patients

From: Metagenomic next-generation sequencing for the early diagnosis of talaromycosis in HIV-uninfected patients: five cases report

Patient

Age (years)/Sex (M/F)

Contact rodents

Misdiagnosis duration (Days)

Clinical Manifestations

Time for fungal culture (Days)

Positive specimens for fungal culture

Time for mNGS (Days)

Positive Specimens for mNGS

Reads for mNGS

Outcome

P1

68/M

No

245

Fever, cough, lymphadenectasis

7

Blood

6

BALF

6

Dead

P2

43/F

No

170

Fever, cough, lymphadenectasis

9

BALF, lymph node

6

BALF

414

Improved

P3

49/M

No

222

Fever, thoracalgia, lymphadenectasis

7

Lymph node, purulent secretion

4

Lymph node

23

Improved

P4

45/F

Yes

160

Cough, ostealgia

7

Sputum, BALF

4

BALF

5

Improved

P5

54/M

Yes

88

Fever, erythraPathological fracture

6

BALF

3

Skin

9

Improved

  1. M Male, F Female, BALF Bronchoalveolar lavage fluid