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Table 1 Cases of ascending aortic mycotic pseudoaneurysm formed due to Pseudomonas aeruginosa infection after HTX

From: Pseudoaneurysm of the ascending aorta: case report of a donor-derived Pseudomonas infection in a heart transplant recipient

Age (years)

Sex

Time after HTX (months)

Recent verified infection or events predisposing to infection

Antimicrobial therapy

Surgical treatment

Follow-up (months)

Clinical

outcome

Reference

39

Male

5

Pseudomonas aeruginosa septicaemia and positive urine culture

iv. Tobramycin, ceftazidime (6 weeks)

Resection, end-to-end anastomosis

8

unrelated death

Palac RT,

et al. 1991

26

Male

15

Cystic fibrosis, heart–lung transplantation, Pseudomonas aeruginosa bronchitis

iv. Unspecified antibiotics (61 days)

po. ciprofloxacin (continuously)

Direct repair (autologous pericardium)

5

operation due to recurrence, (resection of pseudoaneurysm and heterologous graft implantation), then unrelated death after 7 months

Cassart M,

et al. 1994

31

Male

2

N/A

N/A

Resection, allograft implantation

N/A

reoperation due to recurrence, then recovered

McGiffin DC,

et al. 1994

60

Male

N/A

Diabetes mellitus, mediastinitis

iv. Unspecified antibiotics (6 weeks)

Repair with allograft patch

34

recovered

Knosalla C,

et al. 1996

N/A

N/A

8

Pseudomonas pneumonia

Unspecified antibiotics (4–6 weeks)

Collagen-sealed vascular graft implantation

2

reoperation due to recurrence, then death due to bleeding through bronchial fistula

Koyanagi T,

et al. 1999

57

Male

29

Infected retained LVAD driveline

(Pseudomonas aeruginosa)

iv. Unspecified antibiotics (≥ 6 weeks)

Resection, prosthetic graft implantation, pectoralis flap

1

recovered

Tang GHL,

et al. 2011

44

Male

1.4

RVAD outflow graft infection, septicaemia (Pseudomonas aeruginosa)

Unspecified antibiotics

After 3 weeks: resection, allograft implantation

N/A

N/A

Mirzaee S,

et al. 2016

45

Male

1.1

Pseudomonas isolated from previous LVAD exit site

iv. Ceftolozane/tazobactam (8 weeks)

po. ciprofloxacin (lifelong)

Resection, allograft implantation

8,3

recovered

Aye C,

et al. 2017

  1. Eight cases of ascending aortic mycotic pseudoaneurysm formed due to P. aeruginosa infection after HTX were found in the literature. All of them were male patients with a median age of 44 years. The median time between HTX and diagnosis was 5 month. Ventricular assist device related infection was common in medical history. Combined surgical and antibiotic treatment was performed, which however resulted in a recurrence rate of 43%. N/A: not available