Table 1 Characteristics of hepatitis A patients by pediatric acute liver failure (PALF−/+) (n = 219), June 2019–Dec 2019, Somalia
Characteristics | PALF (−) | PALF (+) | p value |
|---|---|---|---|
(n = 194) | (n = 25) | ||
Age (mean ± SD) (years) | 6.7 ± 4.8 | 7.1 ± 6.8 | 0.802 |
Gender, N (%) | |||
Male | 116 (88) | 16 (12) | |
Female | 78 (90) | 9 (10) | 0.851 |
Clinical presentation, N (%) | |||
Jaunce | 11 (65) | 6 (35) | |
Fever | 33 (100) | 0 (0) | 0.004* |
Vomiting | 28 (90) | 3 (10) | |
Asymptomatic | 122 (88) | 16 (12) | |
Sonographic findings, N (%) (n = 84) | |||
Normal | 33 (94) | 2 (6) | |
Hepatomegaly | 3 (50) | 3 (50) | |
Ascites | 7 (58) | 5 (42) | < 0.001* |
Cholecystitis | 11 (79) | 3 (21) | |
Hepatomagly + ascites | 1 (20) | 4 (80) | |
Cholecystitis + ascites | 11 (92) | 1 (8) | |
Laboratory results (mean ± SD) | |||
Platelet (× 109/L) | 315 ± 186 | 347 ± 500 | 0.753 |
Total bilirubin (μmol/L) | 22 ± 118 | 247 ± 572 | 0.062 |
Direct bilirubin (μmol/L) | 14 ± 96 | 53 ± 84 | 0.058 |
Albumin (g/L) | 5 ± 11 | 11 ± 14 | 0.038* |
ALT (U/L) | 517 ± 714 | 1420 ± 2118 | 0.045* |
AST (U/L) | 612 ± 936 | 2760 ± 5630 | 0.069 |
APTT (s) | 6 ± 12 | 155 ± 233 | 0.004* |
GGT (U/L) | 57 ± 137 | 54 ± 51 | 0.84 |
INR | 0,3 ± 0,5 | 147 ± 301 | 0.022* |
PT (s) | 3,7 ± 10 | 149 ± 286 | 0.018* |
Clinical results, N (%) | |||
Recovery | 174 (92) | 15 (8) | < 0.001* |
Relaps | 13(72) | 5 (28) | |
Hepatic encephalopathy | 7 (58) | 5 (42) | |
Length of hospital stay (days) (mean ± SD) | 1.61 ± 3.5 | 5.88 ± 5.6 | 0.001* |