Table 3 rpoB mutations found among culture-positive phenotypic RIF-resistant cases
Freq | Culture-based DST (MGIT 960) | CMI (MGIT 960) | GenoType MTBDRplus | Sequencing | ||||
|---|---|---|---|---|---|---|---|---|
INH | RIF | RIF | RpoB | KatG | inhA | RpoB | ||
1 | C1 | R | R | Not done | Δwt2,3,4, D435V | ∆wt, S315T1 | wt pattern | Not done |
2 | C1 | R | R | Not done | Δwt3,4, D435V | ∆wt, S315T1 | wt pattern | Not done |
1 | C1 | R | R | Not done | Δwt3,4, D435V | wt pattern | wt pattern | Not done |
2 | C1 | S | R | Not done | Δwt7, H445Y | wt pattern | wt pattern | Not done |
1 | C1 | R | R | > 4. 0 μg/ml | Δwt8 | wt pattern | wt pattern | L449M + S450F (+++) |
8 | C1 | R | R | Not done | Δwt8, S450L | ∆wt, S315T1 | wt pattern | Not done |
2 | C1 | R | R | Not done | Δwt8, S450L | ∆wt | wt pattern | Not done |
2 | C1 | R | R | Not done | Δwt8, S450L | wt pattern | wt pattern | Not done |
1 | C1 | R | R | > 4. 0 μg/ml | wt pattern | wt pattern | wt pattern | NO mutation |
1 | C2 | R | R | 4.0 μg/ml | wt pattern | ∆wt, S315T1 | wt pattern | L430P* + S493L* |
1 | C2 | R | R | 2.0 μg/ml | Δwt2 | ∆wt, S315T1 | wt pattern | L430P + S493L |
1 | C2 | R | R | 0.5 μg/ml | wt pattern | ∆wt, S315T1 | wt pattern | D435Y* + L452P* |
1 | C2 | R | R | 4.0 μg/ml | Δwt2 | wt pattern | wt pattern | Q432ins |
8 | C2 | R | R | Not done | Δwt2,3,4, D435V | ∆wt, S315T1 | wt pattern | Not done |
2 | C2 | R | R | Not done | Δwt3,4, D435V | ∆wt, S315T1 | wt pattern | Not done |
1 | C2 | R | R | Not done | Δwt3,4, D435V | wt pattern | wt pattern | Not done |
1 | C2 | R | R | 1. 0 μg/ml | Δwt4,5 | wt pattern | wt pattern | N437del (+++) |
1 | C2 | R | R | Not done | Δwt7, H445D | ∆wt, S315T1 | wt pattern | Not done |
1 | C2 | R | R | Not done | Δwt7,8, H445D | ∆wt, S315T1 | wt pattern | Not done |
1 | C2 | R | R | Not done | Δwt7, H445D | wt pattern | wt pattern | Not done |
1 | C2 | R | R | 2. 0 μg/ml | Δwt7 | ∆wt | wt pattern | H445L (+++) |
1 | C2 | R | R | > 4. 0 μg/ml | Δwt8 | ∆wt, S315T1 | wt pattern | S450Y (+++) |
1 | C2 | R | R | > 4. 0 μg/ml | Δwt8 | wt pattern | ∆wt1, C15T | S450F (+++) |
1 | C2 | R | R | > 4. 0 μg/ml | Δwt8 | wt pattern | wt pattern | S450W (+++) |
22 | C2 | R | R | Not done | Δwt8, S450L | ∆wt, S315T1 | wt pattern | Not done |
2 | C2 | R | R | Not done | Δwt8, S450L | ∆wt | wt pattern | Not done |
1 | C2 | R | R | Not done | Δwt8, S450L | wt pattern | ∆wt1, C15T | Not done |
1 | C2 | R | R | Not done | Δwt8, S450L | wt pattern | ∆wt1 | Not done |
1 | C2 | R | R | Not done | Δwt8, S450L | wt pattern | C15T | Not done |
8 | C2 | R | R | Not done | Δwt8, S450L | wt pattern | wt pattern | Not done |
2 | C2 | S | R | Not done | Δwt8, S450L | wt pattern | wt pattern | Not done |
1 | C2 | R | R | < 0.13 μg/ml | wt pattern | wt pattern | wt pattern | NO mutation |