Real-life isoniazid and rifampicin plasma concentrations in children: a tool for therapeutic drug monitoring of tuberculosis

Table 2 Univariate and multivariate analysis of isoniazid concentration considering age, gender and ethnicity

	n (%)	Median plasma concentration μg/ml (IQR)	Univariate analysis p	Multivariate analysis p
Age groups (years)
≤ 2 years	10 (13.7)	0.78 (0.43–1.86)
2–12 years	42 (57.5)	2.27 (1.34–3.39)	0.0024	< 0.001
> 12 years	21 (28.8)	1.55 (0.5–2.47)	< 0.001	< 0.001
Gender
Male	52 (71.2)	2.22 (1.13–3.29)	0.01	0.056
Female	21 (28.8)	0.75 (0.44–1.67)
Ethnicity
African	5 (6.8)	2.61(2.20–3.24)	0.90	0.238
Asiatic	7 (9.6)	0.94 (0.44–4.35)	0.52	0.88
South American	14 (19.2)	2.05 (0.52–2.96)	0.74	0.86
Caucasian	47 (64.4)	1.67 (0.80–3.12)

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