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Table 3 Main clinical, laboratory and instrumental findings regarding the three cases here described

From: Three case reports of West Nile virus neuroinvasive disease: lessons from real-life clinical practice

 

Symptoms

Neurological exam

CSF finding

MRI findings

EEG findings

Management

Outcome

Patient#1

68 yo

Male

Caucasian

Fever, confusion, skin rash

Diplopia, bilateral positive Babinski sign, resistance to head passive mobilization

Mononuclear pleocytosis, hyper-protidorrachia, hypo-glycorrachia

No abnormalities reported

Bilateral slow-wave activity on central-anterior leads

Supportive care; suspension of empiric ABT on diagnosis confirmation

Mild cognitive impairment followed by complete recovery; no relapses reported

Patient#2

66 yo

Male

Caucasian

Headache, cervical pain, nausea, low-grade fever

Slight right upper limb weakness

Mononuclear pleocytosis, slightly increased proteins, hypo-glycorrachia

No abnormalities reported

Minimal bilateral slow-wave activity on temporal leads

Supportive care; suspension of empiric ABT on diagnosis confirmation

Mild cognitive impairment followed by complete recovery; no relapses reported

Patient#3

85 yo

Female

Caucasian

Fever, dysuria, skin rash, disorientation

Nuchal rigidity, diffuse tremors, slurred speech, impaired task execution, focal vision defect

Increased RBC count, polymorphonuclear pleocytosis, hyper-protidorrachia, hypo-glycorrachia

Lobar white matter hyperintensities on T2-weighted sequences

bilateral slow-wave alterations were recorded on central-anterior leads

Supportive care; suspension of empiric ABT on diagnosis confirmation; antiepileptic therapy

Significant motor/cognitive impairment followed by gradual recovery; no relapses reported

  1. ABT antibiotic therapy; RBC red blood cell