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Table 1 Characteristics of the included studies in this study

From: Effect of continuing the use of renin–angiotensin system inhibitors on mortality in patients hospitalized for coronavirus disease 2019: a systematic review, meta-analysis, and meta-regression analysis

Study year

Study design

Country

Sample

Demographics

Comorbidity (%)

ICU (%)

Con

Dis

Age (Year)

Male (%)

CHD

HF

CKD

Diabetes

COPD

Cannata et al. 2020 [30]

Prospective single-center observation

Italy

56

117

NA

NA

NA

NA

NA

NA

NA

NA

Lam et al. 2020 [31]

Retrospective single-center cohort study

America

164

171

68

56.4

24.6

11.3

9.0

45.4

NA

19.4

Chaudhri et al. 2020 [32]

Retrospective single-center cohort study

America

49

31

68.5

60.0

31.0

29.0

19.0

46.0

11.0

28.0

Soleimani 2020 [33]

Retrospective single center observational study

Iran

79

43

68

59.0

NA

NA

12.3

46.7

NA

NA

Lahens et al. 2021 [34]

Retrospective single center cohort study

France

78

39

65

59.0

17.0

13.0

26.0

49.0

6.0

20.5

Aparisi et al. 2022 [35]

Retrospective multi-center

Non experimental comparative study

Spain

151

159

74

47.4

12.7

NA

11.0

26.8

9.6

12.0

de Abajo et al. 2021 [36]

Retrospective multi-center cohort study

Spain

285

340

74

60.6

15.8

11.0

11.5

74

60.6

5.8

Sharma et al. 2022 [37]

Prospective multi-center RCT

Canada

25

21

71.5

56.5

32.6

10.9

19.6

43.5

4.4

6.5

Bauer et al. 2021 [38]

Prospective multi-center RCT

Austria and Germany

100

104

75

63.2

22.0

9.0

18.1

32.8

15.7

23.0

Cohen et al. 2021 [39]

Prospective multi-center RCT

America, Canada, Mexico, Sweden, Peru, Bolivia, and Argentina

75

77

62

55.0

11.8

3.9

19.1

0.5

NA

19.7

Lopes et al. 2021 [40]

Pragmatic, registry based, randomized

Brazil

325

334

55.1

59.6

4.6

1.4

1.4

31.9

NA

NA

  1. Con continuation, Dis* discontinuation, CHD chronic heart disease, HF heart failure, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, ICU intensive care unit, RCT randomized control trail