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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Patients’ failure to adhere to TB treatment was a major challenge that leads to poor treatment outcomes. In Ethiopia, TB treatment success was low as compared with the global threshold. Despite various studies...

    Authors: Kassahun Dessie Gashu, Kassahun Alemu Gelaye and Binyam Tilahun

    Citation: BMC Infectious Diseases 2021 21:725

    Content type: Research article

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  2. Tuberculosis (TB) diagnosis in the context of HIV co-infection remains challenging. Heme oxygenase 1 (HO-1) and neopterin have been validated as potential biomarkers for TB diagnosis. Latent TB infection (LTBI...

    Authors: Esther Uwimaana, Bernard S. Bagaya, Barbara Castelnuovo, David P. Kateete, Anguzu Godwin, Noah Kiwanuka, Christopher C. Whalen and Moses L. Joloba

    Citation: BMC Infectious Diseases 2021 21:711

    Content type: Research article

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  3. Along with the medical development, organ transplant patients increase dramatically. Since these transplant patients take immunosuppressants for a long term, their immune functions are in a suppressed state, p...

    Authors: Gang Fang, Ning-Chang Cheng, Li-Li Huang, Wei-Ping Xie, Chun-Mei Hu and Wei Chen

    Citation: BMC Infectious Diseases 2021 21:629

    Content type: Case report

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  4. Early diagnosis and treatment of Buruli ulcer is critical in order to avoid the debilitating effects of the disease. In this regard, the development of new diagnostic and point of care tools is encouraged. The...

    Authors: Anthony Ablordey, Evans Ahotor, Charles A. Narh, Sandra A. King, Isra Cruz, Joseph M. Ndung’u and Dziedzom K. de Souza

    Citation: BMC Infectious Diseases 2021 21:598

    Content type: Research article

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  5. Psychological distress, a major comorbidities of tuberculosis (TB) patients, has posed a serious threat to the progress being made in global TB programs by affecting treatment adherence and health outcomes. Ho...

    Authors: Xu Chen, Ruiheng Wu, Jia Xu, Jiawei Wang, Mingcheng Gao, Yunting Chen, Yuanping Pan, Haoqiang Ji, Yuxin Duan, Meng Sun, Liang Du and Ling Zhou

    Citation: BMC Infectious Diseases 2021 21:563

    Content type: Research article

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  6. A decision to diagnose certain skin diseases in patient undergoing psychotic break is challenging; this includes establishing the diagnosis of leprosy. Diagnosis of leprosy is established if there is at least ...

    Authors: Hendra Gunawan, Reyshiani Johan, Pati Aji Achdiat and Oki Suwarsa

    Citation: BMC Infectious Diseases 2021 21:540

    Content type: Case report

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  7. Heterozygous mutations in the transcription factor GATA2 result in a wide spectrum of clinical phenotypes, including monocytopenia and Mycobacterium avium complex (MAC) infection (MonoMAC) syndrome. Patients with...

    Authors: Mizuki Haraguchi, Norihiro Harada, Junko Watanabe, Hitomi Yoshikawa, Yukina Shirai, Moegi Komura, Mika Koyama, Jun Ito, Yutaka Tsukune, Yoshiya Horimoto, Takuo Hayashi, Tetsutaro Nagaoka, Toshimasa Uekusa and Kazuhisa Takahashi

    Citation: BMC Infectious Diseases 2021 21:502

    Content type: Case report

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  8. The purpose of this study was to examine the value of Xpert MTB/RIF assay and detection of additional Mycobacterium tuberculosis complex (MTBC) species antigens from intestinal tissue samples in differentiating i...

    Authors: Baoying Fei, Lin Zhou, Yu Zhang, Linhe Luo and Yuanyuan Chen

    Citation: BMC Infectious Diseases 2021 21:498

    Content type: Research article

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  9. Hemoptysis is very common and can be life threatening in clinical practice for nontuberculous mycobacteria. The serum antibody against the Mycobacterium avium complex (MAC-Ab), the majority of nontuberculous myco...

    Authors: Hiroaki Ogata, Atsushi Moriwaki, Taisuke Nakagawa, Soichiro Sakoda, Akiko Ishimatsu, Kazuhito Taguchi, Hiroshi Aso, Hiroko Nogami, Masako Kadowaki, Yuko Tateshi and Makoto Yoshida

    Citation: BMC Infectious Diseases 2021 21:480

    Content type: Research article

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  10. Identifying and treating individuals with high risk of progression from latent tuberculosis infection to active tuberculosis (TB) disease is critical for eliminating the disease. We aimed to conduct a systemat...

    Authors: Jorge R. Ledesma, Jianing Ma, Peng Zheng, Jennifer M. Ross, Theo Vos and Hmwe H. Kyu

    Citation: BMC Infectious Diseases 2021 21:467

    Content type: Research article

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  11. Pulmonary tuberculosis (TB) in people living with HIV (PLH) frequently presents as sputum smear-negative. However, clinical trials of TB in adults often use smear-positive individuals to ensure measurable bact...

    Authors: Edith E. Machowski, Matebogo Letutu, Limakatso Lebina, Ziyaad Waja, Reginah Msandiwa, Minja Milovanovic, Bhavna G. Gordhan, Kennedy Otwombe, Sven O. Friedrich, Richard Chaisson, Andreas H. Diacon, Bavesh Kana and Neil Martinson

    Citation: BMC Infectious Diseases 2021 21:466

    Content type: Research article

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  12. Tuberculosis (TB) and type 2 diabetes mellitus (DM) are global health diseases with high morbidity and mortality. Few studies have focused on platelet indices in TB-DM coinfection patients. The objective of th...

    Authors: Feifan Xu, Shengyan Qu, Lin Wang and Yongwei Qin

    Citation: BMC Infectious Diseases 2021 21:461

    Content type: Research article

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  13. There is a need for innovative strategies to improve TB testing uptake and patient retention along the continuum of TB care early-on in treatment without burdening under-resourced health systems. We used a mix...

    Authors: Stephanie Law, Boitumelo Seepamore, Olivia Oxlade, Nondumiso Sikhakhane, Halima Dawood, Sheldon Chetty, Nesri Padayatchi, Dick Menzies and Amrita Daftary

    Citation: BMC Infectious Diseases 2021 21:449

    Content type: Research article

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  14. Whole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought. Compartmentalized infections, exogenous reinfections, and microevolution ...

    Authors: Darío A. Fernandez Do Porto, Johana Monteserin, Josefina Campos, Ezequiel J. Sosa, Mario Matteo, Federico Serral, Noemí Yokobori, Andrés Fernández Benevento, Tomás Poklepovich, Agustín Pardo, Ingrid Wainmayer, Norberto Simboli, Florencia Castello, Roxana Paul, Marcelo Martí, Beatriz López…

    Citation: BMC Infectious Diseases 2021 21:394

    Content type: Case report

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  15. Migrants are known to be predominantly poor population which are predisposing to social and health problems, particularly infectious diseases including tuberculosis (TB). TB itself and effect of treatment may ...

    Authors: Myo Minn Oo, Naris Boonathapat, Htet Ko Ko Aung, Petchawan Pungrassami and Tippawan Liabsuetrakul

    Citation: BMC Infectious Diseases 2021 21:377

    Content type: Research article

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  16. Recently developed immunosuppressive drugs, especially TNF antagonists, may enhance the risk of granulomatous infections, including leprosy. We aimed to evaluate the leprosy detection rate in patients under im...

    Authors: Daniel Holanda Barroso, Jurema Guerrieri Brandão, Elaine Silva Nascimento Andrade, Ana Clara Banhatto Correia, Danielle Costa Aquino, Ana Carolina Rios Chen, Sebastian Vernal, Wildo Navegantes de Araújo, Lícia Maria Henrique da Mota, Raimunda Nonata Ribeiro Sampaio, Patrícia Shu Kurizky and Ciro Martins Gomes

    Citation: BMC Infectious Diseases 2021 21:347

    Content type: Research article

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  17. The laboratory plays a critical role in tuberculosis (TB) control by providing testing for diagnosis, treatment monitoring, and surveillance at each level of the health care system. Weak accessibility to TB di...

    Authors: Riccardo Alagna, Adjima Combary, Elisa Tagliani, Léon Tinnoga Sawadogo, Tandaogo Saouadogo, Souba Diandé, Francis Ouedraogo and Daniela Maria Cirillo

    Citation: BMC Infectious Diseases 2021 21:346

    Content type: Research article

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  18. To explore population aging and the epidemic trend of pulmonary tuberculosis (PTB) in the elderly, and provide a basis for the prevention and control of pulmonary tuberculosis among the elderly.

    Authors: Shi-jin Li, Yi-fan Li, Wan-mei Song, Qian-yun Zhang, Si-qi Liu, Ting-ting Xu, Qi-qi An, Jin-yue Liu and Huai-chen Li

    Citation: BMC Infectious Diseases 2021 21:302

    Content type: Research article

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  19. The World Health Organization (WHO) End TB strategy aims to reduce mortality due to tuberculosis (TB) to less than 5% by 2035. However, mortality due to multidrug-resistant tuberculosis (MDR-TB) remains partic...

    Authors: Enock Kizito, Joseph Musaazi, Kenneth Mutesasira, Fred Twinomugisha, Helen Namwanje, Timothy Kiyemba, Debora B. Freitas Lopez, Nicholas Sebuliba Nicholas, Abel Nkolo, Estella Birabwa, Seyoum Dejene and Stella Zawedde-Muyanja

    Citation: BMC Infectious Diseases 2021 21:292

    Content type: Research article

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  20. Leprosy continues to be an important cause of physical disability in endemic countries such as Brazil. Knowledge of determinants of these events may lead to better control measures and targeted interventions t...

    Authors: Mauro Niskier Sanchez, Joilda Silva Nery, Júlia Moreira Pescarini, André Alves Mendes, Maria Yury Ichihara, Camila Silveira Silva Teixeira, Maria Lúcia Fernandes Penna, Liam Smeeth, Laura Cunha Rodrigues, Maurício Lima Barreto, Elizabeth B. Brickley and Gerson Oliveira Penna

    Citation: BMC Infectious Diseases 2021 21:290

    Content type: Research article

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  21. Tuberculosis (TB) remains a significant global public health problem. China has the second highest TB burden in the world. With a growing TB population with diabetes mellitus (DM), the TB control system faces ...

    Authors: Wenhui Xiao, Dajiang Huang, Saiqiong Li, Shangcheng Zhou, Xiaolin Wei, Bin Chen and Guanyang Zou

    Citation: BMC Infectious Diseases 2021 21:272

    Content type: Research article

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  22. Rapid identification of pathogenic Mycobacterium species is critical for a successful treatment. However, traditional method is time-consuming and cannot discriminate isolated non-tuberculosis mycobacteria (NTM) ...

    Authors: Qing Zhang, Heping Xiao and Liping Yan

    Citation: BMC Infectious Diseases 2021 21:264

    Content type: Research article

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  23. Pakistan ranks amongst the top 20 highest burden tuberculosis (TB) countries in the world. Approximately 369,548 cases of TB (all forms) were notified in 2018, with an estimated incidence of 265 per 100,000 pe...

    Authors: Mohsin F. Butt, Sidra Younis, Zhenqiang Wu, Syed H. Hadi, Abdullah Latif and Adrian R. Martineau

    Citation: BMC Infectious Diseases 2021 21:210

    Content type: Research article

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  24. Drug susceptibility testing (DST) patterns of Mycobacterium tuberculosis (MTB) from patients with rifampicin-resistant tuberculosis (RR-TB) or multidrug-resistant TB (MDR-TB; or resistant to rifampicin and isonia...

    Authors: Anne-Marie Demers, Soyeon Kim, Sara McCallum, Kathleen Eisenach, Michael Hughes, Linda Naini, Alberto Mendoza-Ticona, Neeta Pradhan, Kim Narunsky, Selvamuthu Poongulali, Sharlaa Badal-Faesen, Caryn Upton, Elizabeth Smith, N. Sarita Shah, Gavin Churchyard, Amita Gupta…

    Citation: BMC Infectious Diseases 2021 21:205

    Content type: Research article

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  25. Non-tuberculous mycobacterial (NTM) infections are increasing worldwide, making them an international public health problem. Surgical management is often indicated for localized infectious disease; however, mo...

    Authors: Yutaka Shishido, Hiroshi Hamakawa, Kazuhiro Minami, Shigeo Hara and Yutaka Takahashi

    Citation: BMC Infectious Diseases 2021 21:196

    Content type: Case report

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  26. Multidrug-resistant tuberculosis (MDR-TB) are unsatisfied to treat, pressing more effective and innovative treatment regimens. New efficient regimens for MDR-TB have obtained high treatment success rates. Howe...

    Authors: Taoping Weng, Feng Sun, Yang Li, Jiazhen Chen, Xinchang Chen, Rong Li, Shijia Ge, Yanlin Zhao and Wenhong Zhang

    Citation: BMC Infectious Diseases 2021 21:183

    Content type: Study protocol

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  27. Tuberculosis (TB) control relies on early diagnosis and treatment. International guidelines recommend systematic TB screening at health facilities, but implementation is challenging. We investigated completion...

    Authors: Helena R. A. Feasey, Elizabeth L. Corbett, Marriott Nliwasa, Luke Mair, Titus H. Divala, Wala Kamchedzera, Mc Ewen Khundi, Helen E. D. Burchett, Emily L. Webb, Hendramoorthy Maheswaran, S. Bertel Squire and Peter MacPherson

    Citation: BMC Infectious Diseases 2021 21:178

    Content type: Research article

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  28. Joint replacement is an effective intervention and prosthetic joint infection (PJI) is one of the most serious complications of such surgery. Diagnosis of PJI is often complex and requires multiple modalities ...

    Authors: Michael Riste, Pretin Davda, E. Grace Smith, David H. Wyllie, Martin Dedicoat, Simantini Jog, Steven Laird, Gerald Langman, Neil Jenkins, Jonathan Stevenson and Matthew K. O’Shea

    Citation: BMC Infectious Diseases 2021 21:151

    Content type: Case report

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  29. Severity of TB increases in refugee populations. Monitoring TB case notification and treatment outcomes are essential to improve the effectiveness of TB programs. This study aimed to investigate trends in TB c...

    Authors: Tsegay Legesse, Goitom Admenur, Selemawit Gebregzabher, Eyob Woldegebriel, Bexabeh Fantahun, Yemane Tsegay, Abeyot Bayssa, Berihu Darge, Yidnekachew Denbu, Hayelom Michalel, Kibebew Abera, Abraham Alemayeh, Dejene Kebede and Desta Kasa

    Citation: BMC Infectious Diseases 2021 21:139

    Content type: Research article

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  30. Correct knowledge about transmission of tuberculosis (TB) can influence better health-seeking behaviors, and in turn, it can aid TB prevention in society. Therefore, this study aimed to examine the prevalence ...

    Authors: Peter A. M. Ntenda, Razak Mussa, Steve Gowelo, Alick Sixpence, Andy Bauleni, Atusayi Simbeye, Alfred Matengeni, Ernest Matola, Godfrey Banda, Christopher C. Stanley, Susan Banda and Owen Nkoka

    Citation: BMC Infectious Diseases 2021 21:132

    Content type: Research article

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  31. Xpert MTB/RIF (Xpert) has been recommended by WHO as the initial diagnostic test for TB and rifampicin-resistance detection. Existing evidence regarding its uptake is limited to public health systems and corre...

    Authors: Sarang Deo, Pankaj Jindal and Sirisha Papineni

    Citation: BMC Infectious Diseases 2021 21:123

    Content type: Research article

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  32. Gene expression signatures have been used as biomarkers of tuberculosis (TB) risk and outcomes. Platforms are needed to simplify access to these signatures and determine their validity in the setting of comorb...

    Authors: W. Evan Johnson, Aubrey Odom, Chelsie Cintron, Mutharaj Muthaiah, Selby Knudsen, Noyal Joseph, Senbagavalli Babu, Subitha Lakshminarayanan, David F. Jenkins, Yue Zhao, Ethel Nankya, C. Robert Horsburgh, Gautam Roy, Jerrold Ellner, Sonali Sarkar, Padmini Salgame…

    Citation: BMC Infectious Diseases 2021 21:106

    Content type: Research article

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  33. Treatment monitoring of drug-resistant tuberculosis (DR-TB) in resource-limited settings is challenging. We developed a multi-analyte assay for eleven anti-TB drugs in small hair samples as an objective metric...

    Authors: John Metcalfe, Peter Bacchetti, Ali Esmail, Andrew Reckers, David Aguilar, Anita Wen, Shu Huo, Winnie R. Muyindike, Judith A. Hahn, Keertan Dheda, Monica Gandhi and Roy Gerona

    Citation: BMC Infectious Diseases 2021 21:99

    Content type: Research article

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  34. Ending the global tuberculosis (TB) epidemic requires a focus on treating individuals with latent TB infection (LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effecti...

    Authors: J. Surey, H. R. Stagg, T. A. Yates, M. Lipman, P. J. White, A. Charlett, L. Muñoz, L. Gosce, M. X. Rangaka, M. Francis, V. Hack, H. Kunst and I. Abubakar

    Citation: BMC Infectious Diseases 2021 21:90

    Content type: Research article

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  35. Chest X-ray (CXR) interpretation remains a central component of the current World Health Organization recommendations as an adjuvant test in diagnosis of smear-negative tuberculosis (TB). With its low specific...

    Authors: Lydia Nakiyingi, John Mark Bwanika, Willy Ssengooba, Frank Mubiru, Damalie Nakanjako, Moses L. Joloba, Harriet Mayanja-Kizza and Yukari C. Manabe

    Citation: BMC Infectious Diseases 2021 21:63

    Content type: Research article

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  36. The World Health Organization (WHO) has endorsed the next-generation Xpert MTB/RIF Ultra (Ultra) cartridge, and Uganda is currently transitioning from the older generation Xpert MTB/RIF (Xpert) cartridge to Ul...

    Authors: A. Andama, D. Jaganath, R. Crowder, L. Asege, M. Nakaye, D. Katumba, J. Mukwatamundu, S. Mwebe, C. F. Semitala, W. Worodria, M. Joloba, S. Mohanty, A. Somoskovi and A. Cattamanchi

    Citation: BMC Infectious Diseases 2021 21:49

    Content type: Research article

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  37. Screening for latent tuberculosis infection (LTBI) among migrant population has become a critical issue for many low tuberculosis (TB) burden countries. Evidence regarding effectiveness of LTBI programs are li...

    Authors: Lisa Kawatsu, Kazuhiro Uchimura and Akihiro Ohkado

    Citation: BMC Infectious Diseases 2021 21:42

    Content type: Research article

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  38. Tuberculous pleural effusion (TPE) is the most common extrapulmonary manifestation and may have lasting effect on lung function. However conventional diagnostic tests for TPE register multiple limitations. Thi...

    Authors: Xinting Yang, Jing Zhang, Qingtao Liang, Liping Pan, Hongfei Duan, Yang Yang, Hua Li, Chao Guo, Qi Sun, Hongyan Jia, Boping Du, Rongrong Wei, Aiying Xing, Zongde Zhang and Xiaoyou Chen

    Citation: BMC Infectious Diseases 2021 21:4

    Content type: Research article

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  39. Acquiring comprehensive insight into the dynamics of Mycobacterium tuberculosis (Mtb) population structure is an essential step to adopt effective tuberculosis (TB) control strategies and improve therapeutic meth...

    Authors: Shima Hadifar, Abolfazl Fateh, Vahid Pourbarkhordar, Seyed Davar Siadat, Shayan Mostafaei and Farzam Vaziri

    Citation: BMC Infectious Diseases 2021 21:2

    Content type: Research article

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  40. Mycobacterium abscessus is a rapidly growing mycobacteria involved in severe infections of the lung, skin, or soft tissue. Macrolides such as clarithromycin are the recommended first line drugs for treatment of M...

    Authors: Meenu Kaushal Sharma, Yanni La, Debra Janella and Hafid Soualhine

    Citation: BMC Infectious Diseases 2020 20:944

    Content type: Research article

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  41. There is scarce evidence that tuberculosis (TB) can cause diabetes in those not previously known to be diabetic. Whilst the World Health Organization (WHO) recommends screening for Diabetes Mellitus (DM) at th...

    Authors: Sonia Menon, Rodolfo Rossi, Alfred Dusabimana, Natasha Zdraveska, Samit Bhattacharyya and Joel Francis

    Citation: BMC Infectious Diseases 2020 20:937

    Content type: Research article

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  42. Diabetes mellitus type 2 (DM) may impede immune responses in tuberculosis (TB) and thus contribute to enhanced disease severity. In this study, we aimed to evaluate DM-mediated alterations in clinical, radiolo...

    Authors: Akhirunnesa Mily, Protim Sarker, Inin Taznin, Delwar Hossain, Md. Ahsanul Haq, S. M. Mostofa Kamal, Birgitta Agerberth, Susanna Brighenti and Rubhana Raqib

    Citation: BMC Infectious Diseases 2020 20:933

    Content type: Research article

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  43. The presentation of pulmonary tuberculosis (PTB) in young children is often clinically indistinguishable from other common respiratory illnesses, which are frequently infections of viral aetiology. As little i...

    Authors: M. M. van der Zalm, E. Walters, M. Claassen, M. Palmer, J. A. Seddon, A.M. Demers, M. L. Shaw, E. D. McCollum, G. U. van Zyl and A. C. Hesseling

    Citation: BMC Infectious Diseases 2020 20:924

    Content type: Research article

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  44. High rates of Adverse Events (AEs) during treatment is one of the leading causes of unsuccessful treatment outcomes among patients with drug resistant tuberculosis (DR-TB). However, information related to AEs ...

    Authors: Arjunkumar Jakasania, Kalpita Shringarpure, Dixit Kapadia, Radhika Sharma, Kedar Mehta, Arpit Prajapati and Soundappan Kathirvel

    Citation: BMC Infectious Diseases 2020 20:918

    Content type: Research article

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  45. South Africa has one of the highest tuberculosis incidence rates. Biologic disease-modifying anti-rheumatic drugs are associated with an increased risk of tuberculosis. The objective of this study was to descr...

    Authors: Tessa du Toit, Tonya M. Esterhuizen, Nicki Tiffin, Ahmed A. Abulfathi, Helmuth Reuter and Eric H. Decloedt

    Citation: BMC Infectious Diseases 2020 20:900

    Content type: Research article

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COVID-19 Announcement

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.