Skip to main content

Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

Page 1 of 17

  1. Tuberculosis (TB) remains a major public health concern in many low-income countries accounting for approximately two-thirds of deaths in people living with human immunodeficiency virus (HIV) infection. With p...

    Authors: Henry Dilonga Meriki, Ndze Henry Wung, Kukwah Anthony Tufon, Nyeke James Tony, Irene Ane-Anyangwe and Fidelis Cho-Ngwa

    Citation: BMC Infectious Diseases 2020 20:791

    Content type: Research article

    Published on:

  2. People successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target ...

    Authors: Patrick George Tobias Cudahy, Douglas Wilson and Ted Cohen

    Citation: BMC Infectious Diseases 2020 20:789

    Content type: Research article

    Published on:

  3. Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The Thwaites’ system” and “Lancet consensus scoring system” are utilized to differentiate TBM from bacterial meningiti...

    Authors: Tarek Sulaiman, Sai Medi, Hakan Erdem, Seniha Senbayrak, Derya Ozturk-Engin, Asuman Inan, Rok Civljak, Mihai Nechifor, Ayhan Akbulut, Alexandru Crisan, Muge Ozguler, Mustafa Namiduru, Branislava Savic, Olga Dulovic, Filiz Pehlivanoglu, Gonul Sengoz…

    Citation: BMC Infectious Diseases 2020 20:788

    Content type: Research article

    Published on:

  4. Evaluating the completeness of tuberculosis (TB) notification data is important for monitoring of TB surveillance systems. We conducted an inventory study to calculate TB underreporting in Germany in 2013–2017.

    Authors: Teresa Domaszewska, Basel Karo, Ute Preuss, Christian Kollan, Annicka Reuss, Hans-Peter Blank, Bonita Brodhun, Barbara Hauer, Doris Altmann, Lena Fiebig, Walter Haas and Nita Perumal

    Citation: BMC Infectious Diseases 2020 20:766

    Content type: Research article

    Published on:

  5. A more stringent QuantiFERON-TB Gold In-Tube (QFT) conversion (from negative to positive) definition has been proposed to allow more definite detection of recent tuberculosis (TB) infection. We explored altern...

    Authors: Rosa Sloot, Kwame Shanaube, Mareli Claassens, Lily Telisinghe, Ab Schaap, Peter Godfrey-Faussett, Helen Ayles and Sian Floyd

    Citation: BMC Infectious Diseases 2020 20:760

    Content type: Research article

    Published on:

  6. Molecular epidemiological studies of Mycobacterium tuberculosis (MTB) are the core of current research to find out the association of the M. tuberculosis genotypes with its outbreak and transmission. The high pre...

    Authors: Anamika Gupta, Pallavi Sinha, Vijay Nema, Pramod K. Gupta, Pampi Chakraborty, Savita Kulkarni, Nalin Rastogi and Shampa Anupurba

    Citation: BMC Infectious Diseases 2020 20:752

    Content type: Research article

    Published on:

  7. Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC). Mapping the genetic diversity of MTBC in high TB burden country like Ethiopia is important to understand principles of the disease transmi...

    Authors: Biniam Wondale, Kwon Keehwan, Girmay Medhin, Takele Teklu, Temesgen Mohammed, Samuel Tolosa, Aboma Zewude, Friehiwot Amsalu, Rembert Pieper and Gobena Ameni

    Citation: BMC Infectious Diseases 2020 20:750

    Content type: Research article

    Published on:

  8. Effective active case finding (ACF) activities are essential for early identification of new cases of active tuberculosis (TB) and latent TB infection (LTBI). Accurate diagnostics as well as the ability to ide...

    Authors: Caroline Corbett, Aizat Kulzhabaeva, Tatjana Toichkina, Gulmira Kalmambetova, Sevim Ahmedov, Uladzimir Antonenka, Altyn Iskakova, Dilorom Kosimova, Dasha Migunov, Bakyt Myrzaliev, Evgeni Sahalchyk, Nagira Umetalieva, Monica Vogel, Abdylat Kadyrov and Harald Hoffmann

    Citation: BMC Infectious Diseases 2020 20:746

    Content type: Research article

    Published on:

  9. Children living with sputum smear-positive adult tuberculosis (TB) patients are vulnerable to acquire tubercular infection. Contact tracing is an important strategy to control tubercular infection in the commu...

    Authors: Geetika Srivastava, M. M. A. Faridi and Shiv Sagar Gupta

    Citation: BMC Infectious Diseases 2020 20:720

    Content type: Research article

    Published on:

  10. Mycobacterium bovis could infect patients with immunodeficiency or immunosuppressive conditions via Bacillus Calmette-Guérin (BCG) vaccination. Tuberculosis-related hemophagocytic syndrome (HPS) is reported, but ...

    Authors: Buyun Shi, Ming Chen, Zhi Xia, Shuna Xiao, Wen Tang, Chenguang Qin, Ying Cheng, Tao Huang, Chengjiao Huang, Yong Li and Hui Xu

    Citation: BMC Infectious Diseases 2020 20:711

    Content type: Case report

    Published on:

  11. Intravesical administration of Bacillus Calmette–Guérin (BCG) has proven useful for treatment and prevention of recurrence of superficial bladder cancer and in situ carcinoma. However, fatal side effects such ...

    Authors: Gen Shimizu, Ryota Amano, Itaru Nakamura, Akane Wada, Masanobu Kitagawa and Shuta Toru

    Citation: BMC Infectious Diseases 2020 20:708

    Content type: Case report

    Published on:

  12. To investigate the incidence of active tuberculosis (TB) among COPD patients using fluticasone/salmeterol or budesonide/formoterol, and to identify any differences between these two groups of patients.

    Authors: Tsan-Ming Huang, Kuan-Chih Kuo, Ya-Hui Wang, Cheng-Yi Wang, Chih-Cheng Lai, Hao-Chien Wang, Likwang Chen and Chong-Jen Yu

    Citation: BMC Infectious Diseases 2020 20:706

    Content type: Research article

    Published on:

  13. There is limited research to guide TB treatment specifically in pregnant women and few studies have described the presentation of TB in pregnant women. We aimed to understand TB presentation and treatment outc...

    Authors: Brittney J. van de Water, Meredith B. Brooks, Chuan-Chin Huang, Letizia Trevisi, Leonid Lecca, Carmen Contreras, Jerome Galea, Roger Calderon, Rosa Yataco, Megan Murray and Mercedes C. Becerra

    Citation: BMC Infectious Diseases 2020 20:686

    Content type: Research article

    Published on:

  14. Tuberculosis (TB) control is a primary global health priority but the goal to eliminate TB is being threatened by the increase in incidence of multidrug-resistant tuberculosis (MDR-TB). With this series of sev...

    Authors: Oana Joean, Thea Thiele, Katharina Schütz, Nicolaus Schwerk, Ludwig Sedlacek, Barbara Kalsdorf, Ulrich Baumann and Matthias Stoll

    Citation: BMC Infectious Diseases 2020 20:678

    Content type: Research article

    Published on:

  15. Person-centred care, an internationally recognised priority, describes the involvement of people in their care and treatment decisions, and the consideration of their needs and priorities within service delive...

    Authors: Shona Horter, Beverley Stringer, Nell Gray, Nargiza Parpieva, Khasan Safaev, Zinaida Tigay, Jatinder Singh and Jay Achar

    Citation: BMC Infectious Diseases 2020 20:675

    Content type: Research article

    Published on:

  16. Mycobacterium jacuzzii (M. jacuzzii) was first isolated in 2003 by insertion of breast implants in Tel Aviv, Israel. In this case report, we describe our experience in detection of M. jacuzzii using phenotypic an...

    Authors: Fatemeh Sakhaee, Morteza Masoumi, Farzam Vaziri, Seyed Davar Siadat and Abolfazl Fateh

    Citation: BMC Infectious Diseases 2020 20:672

    Content type: Case report

    Published on:

  17. Tuberculosis is still a significant diagnostic and therapeutic challenge with high proportion of smear- and culture- negative incidences worldwide. The conventional diagnostic tests are time-consuming and have...

    Authors: Lingna Lyu, Zihui Li, Liping Pan, Hongyan Jia, Qi Sun, Qiuyue Liu and Zongde Zhang

    Citation: BMC Infectious Diseases 2020 20:657

    Content type: Research article

    Published on:

  18. Tuberculosis (TB) is transmitted in bioaerosols containing Mycobacterium tuberculosis (Mtb). Despite being central to ongoing TB transmission, no routine diagnostic assay exists to measure Mtb in bioaerosols. Fur...

    Authors: Benjamin Patterson, Anastasia Koch, Sophia Gessner, Ryan Dinkele, Melitta Gqada, Wayne Bryden, Frank Cobelens, Francesca Little, Digby F. Warner and Robin Wood

    Citation: BMC Infectious Diseases 2020 20:587

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in BMC Infectious Diseases 2020 20:624

  19. Non-adherence to tuberculosis (TB) treatment is the most important cause of poor TB outcomes, and improving support for TB patients is a primary priority for governments, but there has been little research on ...

    Authors: Xu Chen, Liang Du, Ruiheng Wu, Jia Xu, Haoqiang Ji, Yu Zhang, Xuexue Zhu and Ling Zhou

    Citation: BMC Infectious Diseases 2020 20:623

    Content type: Research article

    Published on:

  20. To improve treatment outcomes for tuberculosis (TB), efforts to reduce treatment failure are necessary. The aim of our study was to describe the characteristics of subjects who had failed treatment of tubercul...

    Authors: Hyeon-Kyoung Koo, Jinsoo Min, Hyung Woo Kim, Joosun Lee, Ju Sang Kim, Jae Seuk Park and Sung-Soon Lee

    Citation: BMC Infectious Diseases 2020 20:622

    Content type: Research article

    Published on:

  21. Ratios of different immune cell populations (i.e., monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte ratios) have been studied as a means of predicting future tuberculosis (TB) disease ...

    Authors: Christiaan A. Rees, Dwan B. Pineros, Maryam Amour, Patricia Munseri, Jamila Said, Albert Magohe, Mecky Matee, Kisali Pallangyo and C. Fordham von Reyn

    Citation: BMC Infectious Diseases 2020 20:609

    Content type: Research article

    Published on:

  22. Implementation of an effective Tuberculosis Routine Surveillance System in low-income countries like Tanzania is problematic, despite being an essential tool for the detection and effective monitoring of drug ...

    Authors: Basra Esmail Doulla, Stephen Bertel Squire, Eleanor MacPherson, Esther Stanslaus Ngadaya, Beatrice Kemilembe Mutayoba and Ivor Langley

    Citation: BMC Infectious Diseases 2020 20:594

    Content type: Research article

    Published on:

  23. Treatment of tuberculosis infection (TBI) in individuals at high risk for tuberculosis (TB) disease is a priority for TB elimination in the US. Newly arrived refugees in Middle Tennessee are screened for TBI, ...

    Authors: Adoma Manful, Leslie Waller, Ben Katz, Jason Cummins, Jon Warkentin, Billy Reagon, Joanna Shaw-Kaikai, Yuwei Zhu and Yuri F. van der Heijden

    Citation: BMC Infectious Diseases 2020 20:592

    Content type: Research article

    Published on:

  24. In sub-Saharan Africa (SSA), most prisons are overcrowded with poor ventilation and put prisoners disproportionally at risk of exposure to Mycobacterium tuberculosis (TB) and developing TB infection but are mostl...

    Authors: Desmond Kuupiel, Portia Vezi, Vitalis Bawontuo, Ernest Osei and Tivani P. Mashamba-Thompson

    Citation: BMC Infectious Diseases 2020 20:570

    Content type: Research article

    Published on:

  25. Globally, tuberculosis (TB) is the 10th leading cause of death. Despite no country achieved its target, the world health organization (WHO) proposed a 90–90-90 approach to fastening the end TB strategy. Improv...

    Authors: Kassahun Alemu Gelaye, Getu Debalkie, Tadesse Awoke Ayele, Sintayehu Daba Wami, Malede Mequanent Sisay, Destaw Fetene, Haileab Fekadu Wolde and Temesgen Yihunie Akalu

    Citation: BMC Infectious Diseases 2020 20:579

    Content type: Research article

    Published on:

  26. China ranks second in the world in terms of numbers of tuberculosis (TB) cases and is one of the top three countries with the largest number of multidrug-resistant and rifampicin-resistant TB (MDR/RR-TB). It a...

    Authors: Liwen Zhang, Wei Xing, Jiani Zhou, Rui Zhang, Yong Cheng, Jin Li, Geng Wang, Shili Liu and Ying Li

    Citation: BMC Infectious Diseases 2020 20:576

    Content type: Research article

    Published on:

  27. There is a general dearth of information on extrapulmonary tuberculosis (EPTB). Here, we investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tsh...

    Authors: Doctor B. Sibandze, Beki T. Magazi, Lesibana A. Malinga, Nontuthuko E. Maningi, Bong-Akee Shey, Jotam G. Pasipanodya and Nontombi N. Mbelle

    Citation: BMC Infectious Diseases 2020 20:556

    Content type: Research article

    Published on:

  28. Determine TB-LAM is the first point-of-care test (POC) for HIV-associated tuberculosis (TB) and rapidly identifies TB in those at high-risk for short-term mortality. While the relationship between urine-LAM an...

    Authors: Andrew D. Kerkhoff, Nicky Longley, Nicola Kelly, Anna Cross, Monica Vogt, Robin Wood, Sabine Hermans, Stephen D. Lawn and Thomas S. Harrison

    Citation: BMC Infectious Diseases 2020 20:555

    Content type: Research article

    Published on:

  29. We examined cytokine immune response profiles among contacts to tuberculosis patients to identify immunologic and epidemiologic correlates of tuberculosis.

    Authors: Mary R. Reichler, Christina Hirsch, Yan Yuan, Awal Khan, Susan E. Dorman, Neil Schluger and Timothy R. Sterling

    Citation: BMC Infectious Diseases 2020 20:553

    Content type: Research article

    Published on:

  30. Bacteriological confirmation (BC) proportion among notified pulmonary TB patients in China is among the lowest in the world. This study was to understand the yield of BC using different testing strategies and ...

    Authors: Guoqin Zhang, Yuhua Zhang, Mingting Chen and Fan Zhang

    Citation: BMC Infectious Diseases 2020 20:548

    Content type: Research article

    Published on:

  31. The main advantage of GeneXpert MTB/RIF® (Xpert) molecular diagnostic technology is the rapid detection of M.tuberculosis DNA and mutations associated with rifampicin (RIF) resistance for timely initiation of app...

    Authors: Julia V. Ershova, Grigory V. Volchenkov, Tatiana R. Somova, Tatiana A. Kuznetsova, Natalia V. Kaunetis, Dorothy Kaminski, Olga V. Demikhova, Larisa N. Chernousova, Irina A. Vasilyeva, Eleanor M. Kerr, J. Peter Cegielski and Ekaterina V. Kurbatova

    Citation: BMC Infectious Diseases 2020 20:543

    Content type: Research article

    Published on:

  32. China is a country with a high burden of pulmonary tuberculosis (PTB). Chongqing is in the southwest of China, where the notification rate of PTB ranks tenth in China. This study analyzed the temporal and spat...

    Authors: Ya Yu, Bo Wu, Chengguo Wu, Qingya Wang, Daiyu Hu and Wei Chen

    Citation: BMC Infectious Diseases 2020 20:531

    Content type: Research article

    Published on:

  33. Tuberculosis and intestinal parasites are mostly affecting poor people. They are in a vicious since one is the risk factor for the other. However, the comprehensive report on the burden and co-incidence of int...

    Authors: Ayinalem Alemu, Zebenay Workneh Bitew and Teshager Worku

    Citation: BMC Infectious Diseases 2020 20:510

    Content type: Research article

    Published on:

  34. Tuberculosis is a disease that may affect any organ of the body. Multifocal tuberculosis involving multiple systems with associated symptoms are rare, which makes the diagnosis challenging. Distinguishing mult...

    Authors: Congxiao Wang, Ying Luan, Shifeng Liu, Mingwei Zhao, Hao Zhang, Wei Li, Zixiang Li, Xiaokun Hu and Lijing Peng

    Citation: BMC Infectious Diseases 2020 20:495

    Content type: Case report

    Published on:

  35. In order to effectively combat Tuberculosis, resources to diagnose and treat TB should be allocated effectively to the areas and population that need them. Although a wealth of subnational data on TB is routin...

    Authors: Margo van Gurp, Ente Rood, Razia Fatima, Pushpraj Joshi, Sharat Chandra Verma, Ahmadul Hasan Khan, Lucie Blok, Christina Mergenthaler and Mirjam Irene Bakker

    Citation: BMC Infectious Diseases 2020 20:490

    Content type: Research article

    Published on:

  36. Health-care workers (HCWs) are an epidemiological group with increased exposure to tuberculosis (TB), especially at health-care facilities (HCFs) with poor TB infection control in high-TB-burden settings. Chin...

    Authors: Guojie Wang, Jiying Xu, Bin Huang, Sanyou Gao, Yan Zhuang, Kan Wang, Yanqiu Zhang and Jianguo Jiang

    Citation: BMC Infectious Diseases 2020 20:484

    Content type: Research article

    Published on:

  37. Interferon-γ release assays (IGRA) with Resuscitation promoting factor (Rpf) proteins enhanced tuberculosis (TB) screening and diagnosis in adults but have not been evaluated in children. Children often develo...

    Authors: W. van Loon, M. P. Gomez, D. Jobe, K. L. M. C. Franken, T. H. M. Ottenhoff, M. Coninx, L. Kestens, J. S. Sutherland, B. Kampmann and L. D. Tientcheu

    Citation: BMC Infectious Diseases 2020 20:469

    Content type: Research article

    Published on:

  38. Despite successful clinical outcomes of biologic medications in patients with chronic rheumatic diseases, some considerable adverse effects such as infections remain a major concern. Possibility of tuberculosi...

    Authors: Mohammad-Esmaeil Hejazi, Atefeh Ahmadzadeh, Alireza Khabbazi, Aliasghar Ebrahimi, Maryam Farmani and Yasin Hejazi

    Citation: BMC Infectious Diseases 2020 20:464

    Content type: Research article

    Published on:

  39. Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an important indicator for the effectiveness of a national TB control program. This stud...

    Authors: Tauseef Ahmad, Muhammad Ayub Jadoon, Muhammad Khan, Haroon, Muhammad Mumtaz Khan, Akbar Hussain, Taha Hussein Musa, Muhammad Waqar, Eyasu Ejeta, Manoochehr Karami, Kefyalew Addis Alene and Hui Jin

    Citation: BMC Infectious Diseases 2020 20:463

    Content type: Research article

    Published on:

  40. At present, there are few studies on polymorphism of Mycobacterium tuberculosis (Mtb) gene and how it affects the TB epidemic. This study aimed to document the differences of polymorphisms between tuberculosis ho...

    Authors: Dingwen Lin, Zhezhe Cui, Virasakdi Chongsuvivatwong, Prasit Palittapongarnpim, Angkana Chaiprasert, Wuthiwat Ruangchai, Jing Ou and Liwen Huang

    Citation: BMC Infectious Diseases 2020 20:462

    Content type: Research article

    Published on:

  41. Extra pulmonary manifestation of tuberculosis (TB) accounts for approximately one-half of TB cases in HIV-infected individuals with pleural TB as the second most common location. Even though mycobacteria are c...

    Authors: Tehmina Mustafa, Ida Wergeland, Kamaldeen Baba, Sharad Pathak, Anwar A. Hoosen and Anne Margarita Dyrhol-Riise

    Citation: BMC Infectious Diseases 2020 20:459

    Content type: Research article

    Published on:

  42. Delayed treatment initiation of tuberculosis (TB) increases disease progression and development of complications which may lead to a higher level of infectiousness, clinical severity and increased mortality. B...

    Authors: Kiros Tedla, Girmay Medhin, Gebretsadik Berhe, Afework Mulugeta and Nega Berhe

    Citation: BMC Infectious Diseases 2020 20:456

    Content type: Research article

    Published on:

  43. The emergence of drug-resistant tuberculosis (DR-TB) is a major healthcare concern worldwide. Here, we analyzed age-related trends in DR-TB rates in South Korea.

    Authors: Eung Gu Lee, Jinsoo Min, Ji Young Kang, Sung Kyoung Kim, Jin Woo Kim, Yong Hyun Kim, Hyoung Kyu Yoon, Sang Haak Lee, Hyung Woo Kim and Ju Sang Kim

    Citation: BMC Infectious Diseases 2020 20:446

    Content type: Research article

    Published on:

  44. The disease burden caused by pulmonary tuberculosis (TB) in Sichuan province still persisted at a high level, and large spatial variances were presented across regional distribution disparities. The socio-econ...

    Authors: Lan Xia, Sui Zhu, Chuang Chen, Zheng-Yuan Rao, Yong Xia, Dan-Xia Wang, Pei-Ru Zhang, Jinge He, Ju-Ying Zhang and Jian-Lin Wu

    Citation: BMC Infectious Diseases 2020 20:433

    Content type: Research article

    Published on:

  45. Good’s syndrome (GS) is characterized by immunodeficiency, and can lead to severe infection, which is the most significant complication. Although Mycobacterium rarely causes infection in patients with GS, dissemi...

    Authors: Waki Imoto, Koichi Yamada, Yuriko Hajika, Kousuke Okamoto, Yuka Myodo, Makoto Niki, Gaku Kuwabara, Kazushi Yamairi, Wataru Shibata, Naoko Yoshii, Kiyotaka Nakaie, Kazutaka Yoshizawa, Hiroki Namikawa, Tetsuya Watanabe, Kazuhisa Asai, Hiroshi Moro…

    Citation: BMC Infectious Diseases 2020 20:431

    Content type: Case report

    Published on:

  46. Even though remarkable progress for diagnostics of pulmonary TB has been made, it is still a challenge to establish a definitive diagnosis for extrapulmonary TB (EPTB) in clinical practice. Among all the prese...

    Authors: Weiwei Gao, Yi Zeng and Wei Chen

    Citation: BMC Infectious Diseases 2020 20:409

    Content type: Case report

    Published on:

  47. Challenges accessing nearby health facilities may be a barrier to initiating and completing tuberculosis (TB) treatment. We aimed to evaluate whether distance from residence to health facility chosen for treat...

    Authors: Katherine O. Robsky, Seamus Hughes, Alex Kityamuwesi, Emily A. Kendall, Peter James Kitonsa, David W. Dowdy and Achilles Katamba

    Citation: BMC Infectious Diseases 2020 20:406

    Content type: Research article

    Published on:

  48. Current tools for diagnosing latent TB infection (LTBI) detect immunological memory of past exposure but are unable to determine whether exposure is recent. We sought to identify a whole-blood transcriptome si...

    Authors: Philip Kam Weng Kwan, Balamurugan Periaswamy, Paola Florez De Sessions, Wenwei Lin, James S. Molton, Claire M. Naftalin, Ahmad Nazri Mohamed Naim, Martin L. Hibberd and Nicholas I. Paton

    Citation: BMC Infectious Diseases 2020 20:403

    Content type: Research article

    Published on: