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Tuberculosis and other mycobacterial diseases

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Tuberculosis (TB), an ancient scourge of humanity known for several thousands of years, is still a significant public health challenge in many countries today even though some progress has been made in recent ...

    Authors: Collins Otieno Ogari, Anthony Kebira Nyamache, James Nonoh and Evans Amukoye

    Citation: BMC Infectious Diseases 2019 19:279

    Content type: Research article

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  2. The need for a rapid, molecular test to diagnose tuberculosis (TB) has prompted exploration of TB-LAMP (Eiken; Tokyo, Japan) for use in resource-limited settings. We conducted a systematic review to assess the...

    Authors: Priya B. Shete, Katherine Farr, Luke Strnad, Christen M. Gray and Adithya Cattamanchi

    Citation: BMC Infectious Diseases 2019 19:268

    Content type: Research article

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  3. Mycobacterium avium complex lung disease (MAC-LD) can deteriorate rapidly to become fatal. Reported poor prognostic factors include radiographic findings, undernutrition, anemia and high inflammation test values....

    Authors: Yuuki Bamba, Hiroshi Moro, Nobumasa Aoki, Takeshi Koizumi, Yasuyoshi Ohshima, Satoshi Watanabe, Takuro Sakagami, Toshiyuki Koya, Toshinori Takada and Toshiaki Kikuchi

    Citation: BMC Infectious Diseases 2019 19:263

    Content type: Research article

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  4. Buruli ulcer (BU) is a chronic, necrotizing infectious skin disease caused by Mycobacterium ulcerans. In recent years, there has been a decrease in the number of new cases detected. This study aimed to show the e...

    Authors: Esaï Gimatal Anagonou, Roch Christian Johnson, Yves Thierry Barogui, Ghislain Emmanuel Sopoh, Gilbert Adjimon Ayelo, Akpeedje Carolle Wadagni, Jean Gabin Houezo, Didier Codjo Agossadou and Michel Boko

    Citation: BMC Infectious Diseases 2019 19:247

    Content type: Research article

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  5. In current epidemiology of tuberculosis (TB), heterogeneity in infectiousness among TB patients is a challenge, which is not well studied. We aimed to quantify this heterogeneity and the presence of “super-spr...

    Authors: Yayehirad A. Melsew, Manoj Gambhir, Allen C. Cheng, Emma S. McBryde, Justin T. Denholm, Ee Laine Tay and James M. Trauer

    Citation: BMC Infectious Diseases 2019 19:244

    Content type: Research article

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  6. Nontuberculous mycobacterial (NTM) disease is commonly an opportunistic infection frequently found in immunocompromised individuals, but sometimes can also be found in the immunocompetent hosts, especially in ...

    Authors: Xianli Xu, Xiaojie Lao, Chunlan Zhang, Cunwei Cao, Huarong Ding, Yu Pang, Qiuyue Ning, Jun Zou, Ning Zang, Diefei Hu and Maowei Chen

    Citation: BMC Infectious Diseases 2019 19:203

    Content type: Case report

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  7. In spite of an alarmingly high tuberculosis (TB) burden amongst the Saharia tribe of central India, there is hardly any study to investigate the impact of DOTS implementation on the magnitude of tuberculosis d...

    Authors: V. G. Rao, J. Bhat, R. Yadav, R. K. Sharma and M. Muniyandi

    Citation: BMC Infectious Diseases 2019 19:180

    Content type: Research article

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  8. TB outbreaks in educational institutions can result in significant transmission and pose a considerable threat to TB control. Investigation using traditional microbiological and epidemiological tools can lead ...

    Authors: Simon Packer, Claire Green, Ellen Brooks-Pollock, Katerina Chaintarli, Sarah Harrison and Charles R. Beck

    Citation: BMC Infectious Diseases 2019 19:154

    Content type: Research article

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  9. Vitamin D levels are associated with the extent of mycobactericidal activity. Interleukin (IL)-15 and IL-32 play roles in the vitamin D-mediated tuberculosis (TB) defense mechanism. Vitamin D induces IL-1β, wh...

    Authors: Yoonki Hong, Youngmi Kim, Jae Jun Lee, Myung Goo Lee, Chang Youl Lee, Youlim Kim, Jeongwon Heo, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim and Ji Young Hong

    Citation: BMC Infectious Diseases 2019 19:151

    Content type: Research article

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  10. Empirical treatment of tuberculosis (TB) may be necessary in patients with negative or no Xpert MTB/RIF results. In a context with access to Xpert, we assessed mortality in the 6 months after the initial TB co...

    Authors: Helena Huerga, Gabriella Ferlazzo, Stephen Wanjala, Mathieu Bastard, Paolo Bevilacqua, Elisa Ardizzoni, Joseph Sitienei and Maryline Bonnet

    Citation: BMC Infectious Diseases 2019 19:132

    Content type: Research article

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  11. The tuberculin skin test (TST) and interferon-gamma-release-assays (IGRAs) are utilized in screening programmes for presumed latent tuberculosis infection (LTBI) in health care workers (HCWs). However, inter-t...

    Authors: Shahieda Adams, Rodney Ehrlich, Roslynn Baatjies, Nandini Dendukuri, Zhuoyu Wang and Keertan Dheda

    Citation: BMC Infectious Diseases 2019 19:131

    Content type: Research article

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  12. Tuberculosis (TB) is the leading cause of death from an infectious disease and the roll-out of rapid molecular diagnostics for rifampin resistance has resulted in a steady rise in the number of patients with m...

    Authors: Saumu Pazia Juma, Athanasia Maro, Suporn Pholwat, Stellah G. Mpagama, Jean Gratz, Alphonse Liyoyo, Eric R. Houpt, Gibson S. Kibiki, Blandina T. Mmbaga and Scott K. Heysell

    Citation: BMC Infectious Diseases 2019 19:129

    Content type: Research article

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  13. Pyrazinamide (PZA) is an important component of first-line drugs because of its distinctive capability to kill subpopulations of persistent Mycobacterium tuberculosis (MTB). The prodrug (PZA) is converted to its ...

    Authors: Muhammad Tahir khan, Shaukat Iqbal Malik, Sajid Ali, Nayyer Masood, Tariq Nadeem, Anwar Sheed Khan and Muhammad Tanvir Afzal

    Citation: BMC Infectious Diseases 2019 19:116

    Content type: Research article

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  14. Osteoarticular tuberculosis is a great masquerader presenting in varied forms and in atypical locations, and it is prone to misdiagnosis and missed diagnosis. Isolated acromioclavicular joint tuberculosis has ...

    Authors: Jian Cheng, Shiming Feng, Huining Lei, Weiling Huo and Huanhuan Feng

    Citation: BMC Infectious Diseases 2019 19:111

    Content type: Case report

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  15. Community-based GeneXpert MTB/RIF testing may increase detection of prevalent TB in the community and improve rates of TB treatment completion.

    Authors: Ingrid V. Bassett, Leah S. Forman, Sabina Govere, Hilary Thulare, Simone C. Frank, Bright Mhlongo and Elena Losina

    Citation: BMC Infectious Diseases 2019 19:110

    Content type: Research article

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  16. To investigate the status of anti-tuberculosis treatment in critically ill patients, and to explore the value of APACHE-II score in guiding anti-tuberculosis treatment.

    Authors: Junke Qiu, Caihong Wang, Xiaohong Pan, Lei Pan, Xiaoqing Huang, Jiekun Xu, Xiaobo Ji and Minjie Mao

    Citation: BMC Infectious Diseases 2019 19:106

    Content type: Research article

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  17. With great changes over the past 10 years in China, especially the rapid economic development, population mobility, urbanization and aging, dynamic change on risk of delay, to our knowledge, has not been well ...

    Authors: Hongguang Chen, Tingwei Wang, Lin Liu, Donglin Wang and Qingxue Cheng

    Citation: BMC Infectious Diseases 2019 19:100

    Content type: Research article

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  18. Erythema induratum of Bazin (EIB) – nodular vasculitis associated with Mycobacterium tuberculosis (TB) – and Tuberculosis-Associated Ocular Inflammation (TB-AOI) represent uncommon manifestations of TB. There is ...

    Authors: William J. Connors, Dina A. Fisher, Dennis Y. Kunimoto and Julie M. Jarand

    Citation: BMC Infectious Diseases 2019 19:97

    Content type: Research article

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  19. Lesotho has one of the highest rates of tuberculosis (TB) incidence and TB-HIV co-infection in the world. Our study aimed to assess the knowledge, attitude and associated factors towards TB in the general popu...

    Authors: Tegene Regassa Luba, Shangfeng Tang, Qiaoyan Liu, Simon Afewerki Gebremedhin, Matiko D. Kisasi and Zhanchun Feng

    Citation: BMC Infectious Diseases 2019 19:96

    Content type: Research article

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  20. India has the world’s highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment (“Short Course”) for previously un...

    Authors: Zarir F. Udwadia, Jeffrey A. Tornheim, Shashank Ganatra, Andrea DeLuca, Camilla S. Rodrigues and Amita Gupta

    Citation: BMC Infectious Diseases 2019 19:94

    Content type: Research article

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  21. Tuberculosis is a major challenge to health in the developing world. Triage prior to diagnostic testing could potentially reduce the volume of tests and costs associated with using the more accurate, but costl...

    Authors: Abu A. M. Shazzadur Rahman, Ivor Langley, Rafael Galliez, Afrânio Kritski, Ewan Tomeny and S. Bertel Squire

    Citation: BMC Infectious Diseases 2019 19:93

    Content type: Research article

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  22. TB transmission in healthcare facilities is an important public health problem, especially in the often-overcrowded settings of HIV treatment scale-up. The problem is compounded by the emergence of drug resist...

    Authors: A. Roderick Escombe, Eduardo Ticona, Víctor Chávez-Pérez, Manuel Espinoza and David A. J. Moore

    Citation: BMC Infectious Diseases 2019 19:88

    Content type: Research article

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  23. The understanding of early events following TB exposure is limited by traditional tests that rely on detection of an immune response to infection, which is delayed, or on imaging tests with low sensitivity for...

    Authors: James S. Molton, Benjamin A. Thomas, Yan Pang, Lih Kin Khor, James Hallinan, Claire M. Naftalin, John J. Totman, David W. Townsend, Tow Keang Lim, Cynthia Bin Eng Chee, Yee Tang Wang and Nicholas I. Paton

    Citation: BMC Infectious Diseases 2019 19:83

    Content type: Research article

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  24. Understanding the explanations behind unsuccessful treatment outcomes in tuberculosis (TB) patients is important to improve treatment success. Treatment completion for TB is the mainstay of TB prevention and c...

    Authors: Madeeha Laghari, Syed Azhar Syed Sulaiman, Amer Hayat Khan and Naheed Memon

    Citation: BMC Infectious Diseases 2019 19:82

    Content type: Research article

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  25. Every year around 4 million people with tuberculosis (TB) are not detected. Thus may not get the medical care that they need and deserve from their respective health systems. Ethiopia is included in the 12 cou...

    Authors: Dawit Assefa, Feleke Belachew, Getachew Wondimagegn and Eveline Klinkenberg

    Citation: BMC Infectious Diseases 2019 19:60

    Content type: Research article

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  26. Tuberculosis (TB) remains a major public health concern on a global scale, especially in developing nations. So far, no formal guidelines are available for the diagnosis and treatment of tuberculosis pleurisy....

    Authors: Yimin Tang, Juanjuan Zhang, Huarong Huang, Xing He, Jiaohong Zhang, Min Ou, Guobao Li, Changchun Zeng, Taosheng Ye, Lili Ren, Yingxia Liu and Guoliang Zhang

    Citation: BMC Infectious Diseases 2019 19:55

    Content type: Research article

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  27. Leprosy is an ideal human disease to study T cell regulation as patients show correlation between cytokine skewed Th1-Th2 responses and clinical forms of the disease. The Role of transcription factors on the m...

    Authors: Rajni Upadhyay, Bhavyata Dua, Bhawna Sharma, Mohan Natrajan, Ajai Kumar Jain, Balaji Kithiganahalli Narayanaswamy and Beenu Joshi

    Citation: BMC Infectious Diseases 2019 19:52

    Content type: Research article

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  28. Nigeria accounts for a significant proportion of the global drug-resistant tuberculosis (DR-TB) burden, a large proportion of which goes untreated. Different models for managing DR-TB treatment with varying le...

    Authors: Florence O. Bada, Evaezi Okpokoro, Nick Blok, Emmanuel Meribole, Saswata Dutt, Patrick Dakum, Alash’le Abimiku, Alice Zwerling and Sandra V. Kik

    Citation: BMC Infectious Diseases 2019 19:41

    Content type: Research article

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  29. Bovine tuberculosis is among the primary zoonotic disease caused by Mycobacterium bovis which has significant impact on the health of livestock and human. It has been significantly a cause for great economic loss...

    Authors: Jelalu Kemal, Berhanu Sibhat, Aklilu Abraham, Yitagele Terefe, Ketema Tafess Tulu, Kiros Welay and Nejib Getahun

    Citation: BMC Infectious Diseases 2019 19:39

    Content type: Research article

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  30. Transmission patterns in high tuberculosis incidence areas in England are poorly understood but need elucidating to focus contact tracing. We study transmission within and between age, ethnic and immigrant gro...

    Authors: Emilia Vynnycky, Adrienne R. Keen, Jason T. Evans, Shaina Khanom, Peter M. Hawkey, Richard G. White and Ibrahim Abubakar

    Citation: BMC Infectious Diseases 2019 19:26

    Content type: Research article

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  31. Crohn’s disease is a chronic enteritis of humans that affects the gastrointestinal tract, especially the terminal ileum, cecum and colon. The etiology of this disease is still unknown but seems to be multifact...

    Authors: Forough Zarei-Kordshouli, Bita Geramizadeh and Azizollah Khodakaram-Tafti

    Citation: BMC Infectious Diseases 2019 19:23

    Content type: Research article

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  32. Early detection of leprosy and multidrug therapy are crucial to achieve zero transmission and zero grade II incapacities goals of World Health Organization. Leprosy is difficult to diagnose because clinical fo...

    Authors: André Luiz Leturiondo, Ariani Batista Noronha, Monik Oney Oliveira do Nascimento, Cynthia de Oliveira Ferreira, Fabíola da Costa Rodrigues, Milton Ozório Moraes and Carolina Talhari

    Citation: BMC Infectious Diseases 2019 19:22

    Content type: Research article

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  33. The GeneXpert MTB/RIF Assay (Xpert®) is known to be a feasible, effective and a hopeful tool for rapid tuberculosis (TB) diagnosis and treatment. However, little is known about the time delay caused by initial...

    Authors: Miguelhete Lisboa, Inês Fronteira, Estefano Colove, Marques Nhamonga and Maria do Rosário O. Martins

    Citation: BMC Infectious Diseases 2019 19:18

    Content type: Research article

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  34. Subclinical tuberculosis is an asymptomatic disease phase with important relevance to persons living with HIV. We describe the prevalence, clinical characteristics, and risk of mortality for HIV-infected adult...

    Authors: Kristina L. Bajema, Ingrid V. Bassett, Sharon M. Coleman, Douglas Ross, Kenneth A. Freedberg, Anna Wald and Paul K. Drain

    Citation: BMC Infectious Diseases 2019 19:14

    Content type: Research article

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  35. Making an accurate prognosis for mortality during tuberculosis (TB) treatment in TB-diabetes (TB-DM) comorbid patients remains a challenge for health professionals, especially in low TB prevalent populations, ...

    Authors: Duc T. Nguyen and Edward A. Graviss

    Citation: BMC Infectious Diseases 2019 19:10

    Content type: Research article

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  36. To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality.

    Authors: Jaime Soria, Tatiana Metcalf, Nicanor Mori, Renee E. Newby, Silvia M. Montano, Luz Huaroto, Eduardo Ticona and Joseph R. Zunt

    Citation: BMC Infectious Diseases 2019 19:9

    Content type: Research article

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  37. Accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis in clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and management of multidrug-resistant tuberculosis ...

    Authors: Noura M. Al-Mutairi, Suhail Ahmad, Eiman Mokaddas, Hanaa S. Eldeen and Susan Joseph

    Citation: BMC Infectious Diseases 2019 19:3

    Content type: Research article

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  38. Lebanon hosts a heterogeneous population coming from underdeveloped and developing countries, resulting in increasing incidences of tuberculosis over the past years. The genetic heterogeneity and lineages asso...

    Authors: Balig Panossian, Tamara Salloum, George F. Araj, Georges Khazen and Sima Tokajian

    Citation: BMC Infectious Diseases 2018 18:710

    Content type: Research article

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  39. Abdominal tuberculosis (TB) is an uncommon form of infection with Mycobacterium tuberculosis in Korea. In this study, we aimed to highlight the clinical features, diagnostic methods, and outcomes of abdominal TB ...

    Authors: Jin-Kyu Cho, Young Min Choi, Sang Soo Lee, Hye Kyong Park, Ra Ri Cha, Wan Soo Kim, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok Jae Lee

    Citation: BMC Infectious Diseases 2018 18:699

    Content type: Research article

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  40. Prompt diagnosis of active tuberculosis (TB) has paramount importance to reduce TB morbidity and mortality and to prevent the spread of Mycobacterium tuberculosis. Few studies so far have assessed the diagnostic ...

    Authors: Anna Maria Peri, Davide Paolo Bernasconi, Nadia Galizzi, Alberto Matteelli, Luigi Codecasa, Vincenza Giorgio, Antonio Di Biagio, Fabio Franzetti, Antonella Cingolani, Andrea Gori and Giuseppe Lapadula

    Citation: BMC Infectious Diseases 2018 18:690

    Content type: Research article

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  41. Contact tracing for tuberculosis (TB) is a recommended measure to improve the case detection rate; however, actual implementation in Myanmar is limited and low detection rates have been reported. Household con...

    Authors: Kyaw Ko Ko Htet, Tippawan Liabsuetrakul, Saw Thein, Edward B. McNeil and Virasakdi Chongsuvivatwong

    Citation: BMC Infectious Diseases 2018 18:660

    Content type: Research article

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  42. Nontuberculous mycobacteria (NTM) lung diseases are increasingly recognized as chronic opportunistic infections, occurring in individuals with a wide variety of underlying conditions. In the absence of systemi...

    Authors: Judith Provoost, Florent Valour, Delphine Gamondes, Sandrine Roux, Nathalie Freymond, Emilie Perrot, Pierre-Jean Souquet, Lize Kiakouama-Maleka, Christian Chidiac, Gérard Lina, Oana Dumitrescu, Agathe Sénéchal and Florence Ader

    Citation: BMC Infectious Diseases 2018 18:659

    Content type: Research article

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  43. The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the associ...

    Authors: Yi Liu, Xuxia Zhang, Yuqing Zhang, Yong Sun, Cong Yao, Wei Wang and Chuanyou Li

    Citation: BMC Infectious Diseases 2018 18:658

    Content type: Research article

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  44. This study investigated the treatment outcomes, and factors affecting the outcomes, of new tuberculosis (TB) patients in Busan, South Korea.

    Authors: Jeongha Mok, Daeseong An, Seoungjin Kim, Miyoung Lee, Changhoon Kim and Hyunjin Son

    Citation: BMC Infectious Diseases 2018 18:655

    Content type: Research article

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  45. Tuberculosis (TB) caused an estimated 1.4 million deaths and 10.4 million new cases globally in 2015. TB rates in the United States continue to steadily decline, yet rates in the State of Hawaii are perenniall...

    Authors: Kent J. Koster, Angela Largen, Jeffrey T. Foster, Kevin P. Drees, Lishi Qian, Ed Desmond, Xuehua Wan, Shaobin Hou and James T. Douglas

    Citation: BMC Infectious Diseases 2018 18:608

    Content type: Research article

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  46. Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of ...

    Authors: N. B. Hoa, P. D. Phuc, N. T. Hien, V. Q. Hoa, P. H. Thuong, P. T. Anh and N. V. Nhung

    Citation: BMC Infectious Diseases 2018 18:603

    Content type: Research article

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  47. Successful treatment of latent tuberculosis infection (LTBI) is essential to reduce tuberculosis (TB) incidence rates in low-burden countries. This study measures treatment completion and determinants of non-c...

    Authors: Yvette Louise Schein, Tesfaye Madebo, Hilde Elise Andersen, Trude Margrete Arnesen, Anne Ma Dyrhol-Riise, Hallgeir Tveiten, Richard A. White and Brita Askeland Winje

    Citation: BMC Infectious Diseases 2018 18:587

    Content type: Research article

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