Table 4 In vivo pharmacodynamic parameters of generic and innovator products of oxacillin by nonlinear regression from 4 independent experiments.
OXACILLIN (OXA) PRODUCTS | Emax(log10CFU/g) | SEM | N | SEM | ED50(mg/kg) | SEM | BD (mg/kg) | SEM | 1 LKD (mg/kg) | SEM | Adj. R2 | Sy|x | P (CFA) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OXA-BMS (innovator) | 5.42 | 0.08 | 1.73 | 0.13 | 45.19 | 2.32 | 62.24 | 3.07 | 108.36 | 7.32 | 0.99 | 0.23 | NA |
OXA-BLA | 3.38 | 0.10 | 3.29 | 0.79 | 19.38 | 2.65 | >750.00 | - | >750.00 | - | 0.98 | 0.21 | <0.0001 |
OXA-CAR | 3.69 | 0.10 | 1.81 | 0.20 | 25.44 | 2.20 | 97.61 | 16.13 | >750.00 | - | 0.99 | 0.17 | <0.0001 |
OXA-COL | 3.14 | 0.12 | 1.93 | 0.36 | 35.41 | 3.71 | 132.29 | 33.04 | >750.00 | - | 0.98 | 0.20 | <0.0001 |
OXA-MEM | 3.51 | 0.12 | 2.09 | 0.32 | 23.07 | 2.65 | >750.00 | - | >750.00 | - | 0.96 | 0.32 | <0.0001 |
OXA-OPH | 3.11 | 0.15 | NS | - | NS | - | >750.00 | - | >750.00 | - | 0.96 | 0.31 | <0.0001* |
OXA-QIM | 2.22 | 0.10 | 2.72 | 0.60 | 25.00 | 3.95 | >750.00 | - | >750.00 | - | 0.96 | 0.20 | <0.0001 |
OXA-SCA | 3.66 | 0.17 | 2.03 | 0.46 | 19.31 | 3.02 | >750.00 | - | >750.00 | - | 0.95 | 0.31 | <0.0001 |
OXA-SER† | - | - | - | - | - | - | - | - | - | - | - | - | NA |
OXA-VIT | 3.01 | 0.12 | 1.55 | 0.26 | 18.51 | 2.50 | >750.00 | - | >750.00 | - | 0.97 | 0.20 | <0.0001 |