Skip to main content

Table 5 Sensitivity, Specificity, PPV and NPV of Current WHO TLC thresholds and Proposed new raised TLC thresholds to Identify Severely Immuno-suppressed Children

From: Utility of total lymphocyte count as a surrogate marker for CD4 counts in HIV-1 infected children in Kenya

Age group in months Current WHO TLC threshold (cells/mm3) Sensitivity Specificity PPVa NPVb No. of children
<12 4000 25 100 100 37 82
12-35 3000 23 98 93 58 129
36-59 2500 33 92 68 74 118
>59 2000 62 83 74 74 158
ALL   36c 93c 84c 61c 487
Age group in months Proposed Optimal TLC Sensitivity Specificity PPV NPV No. of Children
<12 7000 71 73 85 54 82
12-35 6000 65 62 61 65 129
36-59 4500 60 54 37 71 118
>59 3000 86 68 68 87 158
ALL   71 64 63 69 487
  1. aPPV = positive predictive value bNPV = negative predictive value cMean value for the four age groups