Table 2 Multivariate analysis of variables associated with mortality in patients with S. aureus bacteremia
Variable | Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | |||
Demographic characteristics | ||||||
Age | ||||||
0-9 | 4.2 | (1.7, 10.3) | 0.002 | 5.1 | (1.7, 15.3) | 0.004 |
10-19 | 1.3 | (0.4, 4.3) | 0.682 | 2.4 | (0.6, 10.0) | 0.213 |
20-29 (reference) | 1.0 | 1.0 | ||||
30-39 | 2.4 | (1.0, 6.0) | 0.059 | 2.7 | (0.9, 8.4) | 0.078 |
40-49 | 4.8 | (2.1, 11.2) | <0.001 | 7.1 | (2.5, 19.9) | <0.001 |
50-59 | 7.1 | (3.1, 16.4) | <0.001 | 8.5 | (3.1, 23.6) | <0.001 |
60-69 | 10.6 | (4.7, 24.1) | <0.001 | 14.8 | (5.4, 40.6) | <0.001 |
70-79 | 18.8 | (8.3, 42.6) | <0.001 | 23.8 | (8.7, 65.1) | <0.001 |
80-89 | 29.3 | (12.9, 66.3) | <0.001 | 38.1 | (13.9, 104) | <0.001 |
90+ | 46.2 | (19.8, 108) | <0.001 | 54.4 | (19.1, 154) | <0.001 |
Sex | ||||||
Female | 1.0 | |||||
Male | 1.0 | (0.9, 1.2) | 0.838 | |||
Ethnicity | ||||||
Indigenous | 1.0 | |||||
Asian | 2.7 | (1.7, 4.2) | <0.001 | |||
Caucasian | 3.1 | (2.2, 4.3) | <0.001 | |||
Polynesian | 1.7 | (0.9, 3.4) | 0.131 | |||
Other | 1.7 | (1.0, 3.0) | 0.052 | |||
IRSAD quintile | ||||||
1 | 1.0 | |||||
2 | 1.3 | (1.0, 1.7) | 0.033 | |||
3 | 1.3 | (1.0, 1.6) | 0.050 | |||
4 | 1.2 | (1.0, 1.5) | 0.091 | |||
5 | 1.3 | (1.0, 1.6) | 0.026 | |||
Risk factors and Acquisition | ||||||
Dialysis | ||||||
No | 1.0 | |||||
Yes | 0.7 | (0.5, 0.8) | <0.001 | |||
IDU | ||||||
No | 1.0 | |||||
Yes | 0.3 | (0.2, 0.4) | <0.001 | |||
Acquisition | ||||||
Community onset | 1.0 | |||||
Community onset HCA | 2.1 | (1.7, 2.5) | <0.001 | 1.4 | (1.1,1.7) | 0.011 |
Nosocomial | 2.4 | (2.0, 2.9) | <0.001 | 1.5 | (1.2,1.9) | 0.001 |
Microbiology and antibiotics | ||||||
Susceptibility | ||||||
MSSA | 1.0 | |||||
cMRSA | 1.3 | (1.0, 1.6) | 0.025 | |||
eMRSA | 2.0 | (1.7, 2.3) | <0.001 | |||
Antibiotic treatment | ||||||
β-lactam | 1.0 | |||||
Glycopeptide | 2.0 | (1.7, 2.3) | <0.001 | 1.5 | (1.3, 1.8) | <0.001 |
Other | 2.1 | (1.6, 2.8) | <0.001 | 1.6 | (1.2, 2.2) | 0.002 |
Clinical infection | ||||||
Primary focus | ||||||
SSTI | 1.0 | 1.0 | ||||
Device with 2° infection | 1.8 | (1.2, 2.7) | 0.003 | 1.9 | (1.3, 2.9) | 0.003 |
Device with no 2° infection | 0.8 | (0.7, 1.0) | 0.118 | 0.9 | (0.7, 1.2) | 0.600 |
IE Left sided | 1.5 | (1.0, 2.1) | 0.025 | 2.2 | (1.5, 3.2) | <0.001 |
IE Right sided | 0.6 | (0.3, 1.1) | 0.092 | 1.4 | (0.7, 3.0) | 0.308 |
No focus | 1.9 | (1.6, 2.4) | <0.001 | 1.4 | (1.1, 1.9) | 0.011 |
Bone/joint | 0.6 | (0.4, 0.8) | <0.001 | 0.8 | (0.6, 1.1) | 0.228 |
Respiratory | 3.7 | (2.9, 4.8) | <0.001 | 3.6 | (2.7, 4.8) | <0.001 |
Sepsis | 4.4 | (3.5, 5.5) | <0.001 | 4.0 | (3.1, 5.3) | <0.001 |
ICU | ||||||
No | 1.0 | 1.0 | ||||
Yes | 1.8 | (1.5, 2.1) | <0.001 | 2.2 | (1.8, 2.7) | <0.001 |