Variable | Base-Case | Low | High | Source |
---|---|---|---|---|
Epidemiologic/Diagnostic/Treatment Parameters | Â | Â | Â | Â |
Lifetime LTBI progression to active TB | 5% | 1% | 15% | |
Percent of LTBI referrals that are foreign-born | 64% | 30% | 100% | [4] |
Percent of QFT-GIT positivity in BCHD | 57% FB; 36% US | -- | -- | BCHD, [4] |
Prevalence of LTBI in TST-positive referrals | 70% FB; 43% US | 0% | 100% | Calculated;[4] |
Sensitivity of QFT-GIT | 81% | 36% | 100% | |
Specificity of QFT-GIT | 99% | 90% | 100% | [8] |
Percent of LTBI patients treated with 4Rif | 62% | 0% | 100% | BCHD |
LTBI treatment completion for 9INH (4Rif) | 52% (73%) | 25% | 100% | |
Drug-induced liver injury (percent severe) | 1% (0.002%) | 0% | 6% | |
Efficacy of LTBI treatment medications | 0.9 | 0.50 | 1 | |
QFT-GIT Costs | 2012 US$ | Â | Â | Â |
QFT-GIT tubes | $7.10/test | $6.60 | $12.42 | BCHD |
Phlebotomy supplies and clinic supplies | $2.18 | $0.55 | $3.82 | BCHD |
QFT-GIT kit | $23.92/test* | $9.90* | $71.75* | BCHD |
QFT-GIT lab consumables | $3.50/test | $.87 | $6.12 | BCHD |
Total equipment costs for QFT-GIT testing††| $1.14/test | $.29 | $1.99 | BCHD |
Phlebotomist labor for QFT-GIT | $1.60/test | $1.60 | $3.99 | BCHD |
Laboratory labor for QFT-GIT | $2.28/test | $1.48 | $2.52 | BCHD |
Overhead for QFT-GIT testing | $0.53/sample | $0.25 | $2.50 | BCHD |
TB Treatment Costs | Â | Â | Â | Â |
Initial LTBI evaluation labor | $35.04 | $15.88 | $68.29 | BCHD |
Labor LTBI treatment: 9INH | $88.56 | $36.40†| $171†| BCHD |
Labor LTBI treatment: 4Rif | $44.28 | $18.20†| $85.70†| BCHD |
Drug costs 9INH | $26.82/course | $9.27 | $91.35 | BCHD |
Drug costs 4Rif | $102.12/course | $102.12 | $482.60 | BCHD |
Chest x-ray | $100 | $50 | $175 | BCHD |
Mild hepatitis | $41.62 | $0 | $344 | BCHD, [21] |
Severe hepatitis | $124.86 | $41.62 | $23,818 | BCHD, [21] |
Cost of active TB (includes drugs, staff, labs) | $8,568 | $2,142 | $64,195 | |
Utilities | Â | Â | Â | Â |
Well | 1 | Â | Â | [21] |
9INH treatment | 0.95 | .9 | .99 | |
4Rif treatment | 0.99 | .9 | .99 | |
Mild hepatitis | 0.85 | 1 mo | 12 mo | |
Severe hepatitis | 0.40 | 0.1 | 0.4 | |
Active TB ** | 0.85 | 0.5 | 0.9 | [21] |
Fatal TB ** | 0.5 | 0.1 | 0.5 | [21] |
Death | 0 | Â | Â | [21] |