Table 6 Association between maternal cytokine gene polymorphisms and antibody levels to P. falciparum antigens in newborns: multivariate analysis
Antibody response | Maternal cytokine gene (n) | Antibody levels (μg/ml)a(SD) | P |
|---|---|---|---|
IgG to AMA-1 | Â | Â | Â |
|  | IL-10 −1082 genotypes: |  |  |
|  |  GG and GA (270) | 1497.3 (214.0) |  |
|  |  AA (306) | 1638.9 (68.3) | 0.04 b |
|  | IL-13 −1055 genotypes: |  |  |
|  |  CC and CT (481) | 1596.0 (230.8) |  |
|  |  TT (95) | 1444.0 (69.9) | 0.03 b |
IgG to MSP-2/3D7 | Â | Â | Â |
|  | IL-10 −1082 genotypes: |  |  |
|  |  GG and GA (270) | 46.0 (4.1) |  |
|  |  AA (306) | 57.6 (6.5) | 0.08 c |
IgG to GLURP-R0 | Â | Â | Â |
|  | IL-10 −592 genotypes: |  |  |
|  |  CC and CA (485) | 3.2 (0.3) |  |
|  |  AA (91) | 2.2 (0.5) | 0.06 c |
|  | IL-10 −1082 /IL-10 −819 /IL-10 −592 haplotypes: |  |  |
|  |  No or 1 copy IL10-ATA (489) | 3.2 (0.3) |  |
|  |  2 copies IL10-ATA (87) | 2.2 (0.5) | 0.05 c |