+ PI | + NNRTI | ||||||||
---|---|---|---|---|---|---|---|---|---|
(n = 16) | (n = 19) | ||||||||
Parameter* | Month 0 | Month 9 | Month 21 | p, trend | Month 0 | Month 9 | Month 21 | p, trend | p, time X treatment interaction |
CD4 lymphocytes /ml | 240 (153) | 376 (158) | 497 (189) | 0.001 | 241 (131) | 445 (167) | 493 (127) | 0.001 | 0.54 |
Viral load, log10/ml | 5.05 (0.85) | 2.08 (0.85) | 1.62 (0.07) | 0.001 | 5.04 (0.55) | 1.91 (0.88) | 1.59 (0.01) | 0.001 | 0.99 |
Cholesterol, g/l | 1.88 (0.45) | 2.22 (0.66) | 2.29 (0.41) | 0.001 | 1.61 (0.34) | 1.95 (0.46) | 2.03 (0.41) | 0.001 | 0.99 |
HDL-cholesterol, g/l | 0.44 (0.08) | 0.45 (0.10) | 0.52 (0.15) | 0.06 | 0.38 (0.10) | 0.52 (0.16) | 0.56 (0.16) | 0.001 | 0.003 |
Triglycerides, g/l | 1.14 (0.58) | 1.99 (1.68) | 1.75 (0.82) | 0.002 | 0.99 (0.48) | 1.34 (1.64) | 1.31 (0.97) | 0.26 | 0.06 |
Glucose, g/l | 0.84 (0.08) | 0.88 (0.08) | 0.87 (0.07) | 0.14 | 0.83 (0.09) | 0.94 (0.08) | 0.90 (0.07) | 0.001 | 0.08 |
Lactate, mmoles/l | 0.93 (0.28) | 1.06 (0.39) | 1.11 (0.44) | 0.24 | 0.98 (0.28) | 0.94 (0.24) | 0.93 (0.35) | 0.68 | 0.19 |
Albumin, g/l | 39.0 (4.9) | 42.6 (2.0) | 42.5 (2.0) | 0.006 | 41.7 (3.7) | 43.1 (3.5) | 42.9 (2.5) | 0.07 | 0.05 |
Cockroft (ml/min) | 83.9 | 82.9 | 86.1 | 0.73 | 102.3 | 103.1 | 104 | 0.66 | 0.97 |
Waist circumference, cm | 83.2 (11.3) | 87.5 (16.7) | 89.7 (13.7) | 0.04 | 82.3 (7.4) | 82.5 (8.3) | 81.9 (9.1) | 0.51 | 0.03 |
BMI, kg/m2 | 23.6 (3.6) | 25.0 (4.9) | 25.7 (5.5) | 0.02 | 23.9 (3.6) | 24.0 (3.7) | 24.3 (3.7) | 0.73 | 0.03 |
Body Mineral content, kg | 3.02 (0.69) | 2.97 (0.63) | 2.93 (0.58) | 0.06 | 3.11 (0.56) | 3.08 (0.57) | 3.04 (0.53) | 0.008 | 0.58 |
L2-L4 BMD, g/cm2 | 1.234 | 1.182 (0.226) | 1.186 (0.238) | 0.001 | 1.249 (0.178) | 1.232 (0.196) | 1.230 | 0.04 | 0.05 |
(0.234) | (0.176) | ||||||||
Body lean mass, kg | 46.3 (8.8) | 48.2 (10.9) | 48.9 (11.2) | 0.05 | 49.4 (10.3) | 49.6 (9.6) | 49.8 (10.2) | 0.64 | 0.09 |
Body fat mass, kg | 18.4 (8.9) | 20.2 (11.1) | 21.5 (10.4) | 0.02 | 19.4 (10.9) | 19.5 (10.2) | 19.6 (9.4) | 0.79 | 0.05 |
Trunk fat mass, kg | 8.87 (4.38) | 9.43 (5.28) | 10.28 (4.80) | 0.03 | 9.03 (4.69) | 9.12 (4.57) | 9.49 (4.54) | 0.42 | 0.19 |
Legs fat mass, kg | 6.61 (3.39) | 7.51 (4.16) | 8.00 (4.24) | 0.02 | 6.88 (4.18) | 7.29 (4.38) | 7.12 (3.70) | 0.35 | 0.07 |
Total ALP U/l | 168 (37) | 193 (75) | 208 (82) | 0.04 | 173 (49) | 227 (67) | 221 (53) | 0.001 | 0.47 |
Osteocalcin, μg/l | 19.3 (7.6) | 37.8 (15.0) | 29.7 (12.8) | 0.003 | 15.7 (5.1) | 24.5 (8.5) | 22.6 (12.6) | 0.005 | 0.19 |
ß-crosslaps, μg/l | 353 (186) | 552 (267) | 525 (240) | 0.03 | 302 (161) | 582 (277) | 473 (226) | 0.001 | 0.56 |
Calcium, mmoles/l | 2.28 (0.08) | 2.34 (0.10) | 2.36 (0.08) | 0.02 | 2.29 (0.11) | 2.32 (0.15) | 2.32 (0.13) | 0.31 | 0.22 |
25-OH vitamine D3, μg/l | 20.7 (8.2) | 22.1 (9.1) | 16.4 (7.2) | 0.27 | 19.4 (12.0) | 19.5 (12.7) | 15.7 (9.6) | 0.12 | 0.81 |
1,25—diOH-vit D3, ng/l | 49.1 (18.7) | 42.9 (8.3) | 58.9 (16.6) | 0.29 | 49.3 (18.4) | 51.6 (17.6) | 61.1 (14.7) | 0.04 | 0.54 |
Parathormone, ng/l | 34.1 (12.9) | 36.7 (12.7) | 53.4 (20.0) | 0.01 | 35.1 (13.3) | 47.8 (19.6) | 46.5 (12.5) | 0.001 | 0.78 |