May early intervention with high dose intravenous immunoglobulin pose a potentially successful treatment for severe cases of tick-borne encephalitis?

Table 1 Listing of case reports of viral encephalitis patients who were treated with high dose intravenous immunoglobulin (IVIG)

Arboviruses	Encephalitis	Haemorrhagic fever	Refs.
TBEV (flavivirus)	1		[26]
JEV (flavivirus)	2		[28–30]
DENV (flavivirus)		15	[31]
WNV (flavivirus)	15		[34–42]
EEEV (togavirus)	1		[44]
CHIKV (togavirus)	1		[45]
other viruses
influenza A virus	2		[46, 47]
herpes simplex virus	1		[48]
enterovirus	23		[49, 50]
mumps virus	1		[53]

The outcome of IVIG-treatment was mostly favourable in the encephalitis cases. However, three of 15 WNV encephalitis patients died from their disease [34, 38]. IVIG treatment had no influence on platelet recovery in 15 cases of secondary DENV haemorrhagic infection, but caused no adverse events either.

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