Number (%) in cohort | Number (%) experiencing a PR | Follow-up (years) | Rate per 100 person-years (95% CI) | Crude rate ratio (95% CI) | p-value* | Adjusted rate ratio (95% CI) | p-value# | |
---|---|---|---|---|---|---|---|---|
Sex | ||||||||
Male | 86 (55.1) | 15 (17.4) | 72.5 | 20.7 (12.5,34.3) | 1 | 0.26 | 1 | 0.64 |
Female | 70 (44.9) | 17 (24.3) | 55.0 | 30.8 (19.1,49.5) | 1.48 (0.74,2.98) | 0.83 (0.38,1.81) | ||
Age (years) | ||||||||
0-<15 | 13 (8.3) | 3 (23.1) | 9.9 | 30.4 (9.8,94.2) | 2.94 (0.74,11.76) | 0.01 | 2.77 (0.67,11.38) | 0.16 |
15-<60 | 62 (39.7) | 6 (9.7) | 58.1 | 10.3 (4.6,23.0) | 1 | 1 | ||
≥60 | 81 (51.9) | 23 (28.4) | 59.8 | 38.4 (25.5,57.9) | 3.72 (1.51,9.14) | 2.84 (1.12,7.17) | 0.03 | |
Lesion type | ||||||||
Ulcer | 137 (87.8) | 24 (17.5) | 116.0 | 20.7 (13.9,30.9) | 1 | 0.03 | 1 | |
Nodule | 10 (6.4) | 4 (40.0) | 6.3 | 63.3 (23.7,168.6) | 3.06 (1.06,8.81) | 1.98 (0.57,6.91) | 0.29 | |
Oedematous | 9 (5.8) | 4 (44.4) | 5.4 | 73.9 (27.7,196.8) | 3.57 (1.24,10.29) | 3.44 (1.11,10.70) | 0.03 | |
Lesion site | ||||||||
Upper limb | 55 (35.3) | 11 (20.0) | 44.7 | 24.6 (13.9,44.4) | 1 | |||
Lower limb | 99 (63.5) | 21 (21.2) | 80.3 | 25.9 (16.9,39.7) | 1.05 (0.51,2.18) | 0.60 | - | - |
Torso | 2 (1.3) | 0 (0.0) | - | - | - | |||
Lesion position | ||||||||
Proximal | 16 (10.3) | 2 (12.5) | 14.2 | 14.1 (3.5,56.5) | 1 | 0.35 | - | - |
Distal | 140 (89.7) | 30 (21.3) | 113.6 | 26.4 (18.5, 37.8) | 1.87 ( 0.45,7.82) | |||
Over a joint | ||||||||
No | 91 (58.3) | 17 (18.7) | 76.2 | 22.5 (13.9,35.9) | 1 | 0.45 | - | - |
Yes | 65 (41.7) | 15 (23.1) | 51.5 | 29.1 (17.6,48.3) | 1.31 (0.65,2.61) | |||
Positive margins | ||||||||
No | 36 (32.7) | 4 (11.0) | 32.5 | 12.3 (4.6,32.8) | 1 | 0.03 | - | - |
Yes | 74 (67.3) | 20 (27.0) | 56.5 | 35.4 (22.8,54.8) | 2.87 (0.98,8.41) | |||
Any excision | ||||||||
No | 42 (27.0) | 6 (14.3) | 36.5 | 16.5 (7.4, 36.6) | 1 | 0.20 | - | - |
Yes | 114 (73.0) | 26 (22.8) | 91.3 | 28.5 (19.4,41.8) | 1.72 (0.71,4.20) | |||
Major excision | ||||||||
No | 82 (52.6) | 11 (13.4) | 71.9 | 15.3 (8.5,27.6) | 1 | 0.01 | 1 | 0.14 |
Yes | 74 (47.4) | 21 (28.4) | 55.9 | 37.6 (24.5,57.6) | 2.45 (1.18,5.09) | 1.78 (0.82,3.87) | ||
Diabetes | ||||||||
No | 143 (91.7) | 27 (18.9) | 118.9 | 22.7 (15.6,33.1) | 1 | 0.09 | 1 | 0.77 |
Yes | 13 (8.3) | 5 (38.5) | 8.8 | 56.7 (23.6,136.2) | 2.50 (0.96,6.49) | 1.19 (0.37,3.89) | ||
Immune suppression | ||||||||
No | 145 (93.0) | 28 (19.3) | 120.0 | 23.3 (16.1,33.8) | 1 | 0.18 | - | - |
Yes | 11 (7.1) | 4 (36.4) | 7.7 | 51.7 (19.4,137.6) | 2.21 (0.78,6.31) | |||
Rifampicin | ||||||||
No | 9 (5.8) | 2 (22.2) | 7.4 | 26.9 (6.7,107.5) | 1 | 0.92 | - | - |
Yes | 147 (94.2) | 30 (20.4) | 120.3 | 24.9 (17.4,35.7) | 0.93 (0.22,3.88) | |||
Ciprofloxacin | ||||||||
No | 55 (35.3) | 13 (23.6) | 43.5 | 29.9 (17.4,51.5) | 1 | 0.44 | - | - |
Yes | 101 (64.7) | 19 (18.8) | 84.3 | 22.5 (14.5,35.7) | 0.75 (0.37,1.53) | |||
Clarithromycin | ||||||||
No | 108 (69.2) | 24 (22.2) | 87.1 | 27.6 (18.5,41.1) | 1 | 0.40 | - | - |
Yes | 48 (30.8) | 8 (16.7) | 40.7 | 19.7 (9.8,39.3) | 0.71 (0.32,1.59) | |||
Ethambutol | ||||||||
No | 145 (93.0) | 28 (19.3) | 120.1 | 23.3 (16.1,33.8) | 1 | 0.17 | - | - |
Yes | 11 (7.1) | 4 (36.4) | 7.6 | 52.3 (19.6,139.5) | 2.25 (0.79,6.40) | |||
Amikacin | ||||||||
No | 151 (96.8) | 28 (18.5) | 126.0 | 22.2 (15.3,32.2) | 1 | <0.001 | 1 | <0.01 |
Yes | 5 (3.2) | 4 (80.0) | 1.8 | 228.6 (85.8,609.2) | 10.29 (3.61,29.33) | 6.33 (2.09,19.18) | ||
Moxifloxacin | ||||||||
No | 151 (96.8) | 30 (19.9) | 124.6 | 24.1 (16.8,34.4) | 1 | - | ||
Yes | 5 (3.2) | 2 (40.0) | 3.1 | 64.0 (16.0,255.8) | 2.66 (0.64,11.12) | 0.24 | - |