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Table 3 Antifungal susceptibility profile of 320 oral yeast isolates from HIV-infected patients from Kunming, China

From: Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan Province of China

Species (No.)

Antifungal agent

MIC range (μg/mL)

No. of S strains (%)a

No. of S-DD strains (%)b

No. of R strains (%)c

C. albicans (263)

Fluconazole

0.125-64

251 (95.0)

3 (1.1)

9 (3.4)

 

Itraconazole

0.031-16

232 (88.2)

13 (4.9)

18 (6.8)

 

Voriconazole

0.031-16

255 (97.0)

-

8 (3.0)

 

Amphotericin B

0.125-1

263 (100.0)

-

0 (0)

C. glabrata (29)

Fluconazole

0.25-64

23 (79.3)

1 (3.4)

5 (17.2)

 

Itraconazole

0.031-16

7 (24.1)

7 (24.1)

15 (51.7)

 

Voriconazole

0.031-16

25 (86.2)

-

4 (13.8)

 

Amphotericin B

0.25-1

29 (100.0)

-

0 (0)

C. krusei (10)

Fluconazole

8-64

3 (30.0)

5 (50.0)

2 (20.0)

 

Itraconazole

0.125-4

1 (10.0)

3 (30.0)

6 (60.0)

 

Voriconazole

0.063-2

8 (80.0)

-

2 (20.0)

 

Amphotericin B

0.25-1

10 (100.0)

-

0 (0)

C. tropicalis (2)

Fluconazole

64

0 (0)

0 (0)

2 (100)

 

Itraconazole

16

0 (0)

0 (0)

2 (100)

 

Voriconazole

16

0 (0)

-

2 (100)

 

Amphotericin B

0.5-1

2 (100.0)

-

0 (0)

C. parapsilosis (12)

Fluconazole

0.125-1

12 (100.0)

0 (0)

0 (0)

 

Itraconazole

0.031-2

6 (50.0)

4 (33.3)

2 (16.7)

 

Voriconazole

0.031

12 (100.0)

-

0 (0)

 

Amphotericin B

0.25-1

12 (100.0)

-

0 (0)

C. rugosa (1)

Fluconazole

1

1 (100.0)

0 (0)

0 (0)

 

Itraconazole

0.031

1 (100.0)

0 (0)

0 (0)

 

Voriconazole

0.031

1 (100.0)

-

0 (0)

 

Amphotericin B

0.5

1 (100.0)

-

0 (0)

C. norvegensis (1)

Fluconazole

1

1 (100.0)

0 (0)

0 (0)

 

Itraconazole

0.25

1 (100.0)

0 (0)

0 (0)

 

Voriconazole

0.063

1 (100.0)

-

0 (0)

 

Amphotericin B

1

1 (100.0)

-

0 (0)

Pichia ohmeri (1)

Fluconazole

8

1 (100.0)

0 (0)

0 (0)

 

Itraconazole

2

0 (0)

0 (0)

1 (100)

 

Voriconazole

0.125

1 (100.0)

-

0 (0)

 

Amphotericin B

0.5

1 (100.0)

-

0 (0)

Saccharomyces cerevisiae (1)

Fluconazole

16

0 (0)

1 (100.0)

0 (0)

 

Itraconazole

0.25

0 (0)

1 (100.0)

0 (0)

 

Voriconazole

0.125

1 (100.0)

-

0 (0)

 

Amphotericin B

1

1 (100.0)

-

0 (0)

  1. a Susceptible (S) strains were defined by MIC ≤8 μg/mL for fluconazole, ≤0.125 μg/mL for itraconazole, <1 μg/mL for voriconazole and ≤ 1 μg/mL for amphotericin B.
  2. b Susceptible-dose dependent (S-DD) strains were defined by MICs between 16 μg/mL and 32 μg/mL for fluconazole and between 0.25 μg/mL and 0.5 μg/mL for itraconazole.
  3. c Resistant (R) strains were defined by MIC ≥64 μg/mL for fluconazole, ≥1 μg/mL for itraconazole and voriconazole, and >1 μg/mL for amphotericin B.
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BMC Infectious Diseases

ISSN: 1471-2334

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