| Model 1: IRR, unadjusted | Model 2: IRR, adjusted for acute phase response | Model 3: IRR, adjusted for known TB risk factors* | |||
---|---|---|---|---|---|---|
 | Is the host iron status biomarker a risk factor for incident TB in HIV infection? | Does the biomarker remain an independent risk factor after adjusting for a marker of the host acute phase response (baseline α-1-antichymotrypsin concentration)? | Does the biomarker remain an independent risk factor for incident TB in HIV infection after adjusting for baseline age, CD4, body mass index? | |||
Iron factors | IRR (95% CI) | P | IRR (95% CI) | P | IRR (95% CI) | P |
Transferrin, g/L | 0.25 (0.19-0.35) | < 0.001 | 0.30 (0.21-0.43) | < 0.001 | 0.53 (0.33-0.84) | 0.007 |
Transferrin saturation, % | 1.00 (0.99-1.01) | 0.691 | 1.00 (0.99-1.01) | 0.691 | 1.00 (0.99-1.01) | 0.669 |
Ferritin, μg/L | 1.71 (1.49-1.97) | < 0.001 | 1.60 (1.35-1.89) | < 0.001 | 1.26 (1.05-1.51) | 0.014 |
Hemoglobin, g/L | 0.79 (0.73-0.86) | < 0.001 | 0.84 (0.77-0.92) | < 0.001 | 0.88 (0.79-0.98) | 0.023 |
Iron, μmol/L | 0.92 (0.88-0.95) | < 0.001 | 0.94 (0.91-0.97) | < 0.001 | 0.96 (0.92-1.01) | 0.104 |
Transferrin receptor, nmol/L | 1.01 (1.00-1.02) | 0.160 | 1.01 (1.00-1.02) | 0.130 | 1.00 (0.99-1.01) | 0.991 |