Prospective European-wide multicentre study on a blood based real-time PCR for the diagnosis of acute schistosomiasis

Wichmann, Dominic; Poppert, Sven; Von Thien, Heidrun; Clerinx, Joannes; Dieckmann, Sebastian; Jensenius, Mogens; Parola, Philippe; Richter, Joachim; Schunk, Mirjam; Stich, August; Zanger, Philipp; Burchard, Gerd D; Tannich, Egbert

doi:10.1186/1471-2334-13-55

Table 1 Characteristics of patients with acute schistosomiasis fulfilling the inclusion criteria

From: Prospective European-wide multicentre study on a blood based real-time PCR for the diagnosis of acute schistosomiasis

Patient	Region of exposure	Reason for travel	Incubation time [days]⁽¹⁾	Time to diagnosis [days]⁽²⁾	Eosinophils absolute[per μl]	PCR	Serology	Microscopy
1	Rwanda	Tourist	57	62	5.400	pos	pos	S.m.
2	Rwanda	Tourist	33	54	2.090	pos	(pos)	S.m.
3	Mozambique	Occupational	28	42	2.860	pos	pos	Ø
4	Ethiopia	Occupational	27	43	2.650	pos	Ø	Ø
5	Uganda	Occupational	38	56	1.920	pos	pos	Ø
6	Uganda	Occupational	20	32	1.600	pos	pos	n.a.
7	Malawi	Tourist	18	20	1.050	pos	pos	n.a.
8	Mozambique	Tourist	35	56	33.050	pos	Ø	n.a.
9	Yemen	Tourist	40	54	1.540	pos	pos	Ø
10	Malawi	Tourist	27	35	980	pos	Ø	Ø
11⁽³⁾	Kenya	Tourist	94	96	3.220	Ø	pos	Ø
12	Kenya	Tourist	184	302	1.100	pos	pos	Ø
13	Sudan	Occupational	27	33	3.350	pos	Ø	Ø
14	Tanzania	Volunteer	75	88	5.880	pos	pos	n.a.
15	East Africa	Volunteer	127	131	1.760	pos	pos	Ø
16⁽⁴⁾	Kenya	VFR	150	210	n.a.	pos	n.a.	S.m.
17	Uganda	Tourist	24	27	n.a.	pos	pos	n.a.
18	Malawi	Tourist	31	73	3.920	pos	Ø	n.a.
19	East Africa	Volunteer	32	104	4.010	pos	pos	Ø
20	Malawi	Tourist	31	34	1.780	Ø	Ø	Ø
21	Mali	Occupational	23	32	1.140	pos	Ø	Ø
22	Tanzania	Volunteer	62	66	2.800	pos	Ø	Ø
23	Madagascar	Tourist	35	38	2.640	pos	pos	n.a.
24	Madagascar	Occupational	92	261	890	pos	pos	n.a.
25	Madagascar	Occupational	122	152	870	pos	pos	Ø
26	East Africa	Tourist	24	36	3.150	pos	pos	Ø
27	Tanzania	Volunteer	47	76	1.700	pos	pos	S.m.
28	Tanzania	Volunteer	47	80	9.850	pos	pos	Ø
29	Tanzania	Volunteer	62	94	2.310	pos	pos	Ø
30	Tanzania	Volunteer	97	196	2.290	Ø	pos	Ø
31	Madagsacar	Occupational	n.a.	160	1.100	pos	pos	Ø
32	Madagascar	Tourist	17	43	1.020	pos	pos	S.m.
33⁽⁵⁾	Ghana	VRF	31	69	1.200	pos	pos	n.a.
34	Madagascar	Tourist	23	34	1.210	pos	pos	n.a.
35	Uganda	Tourist	41	53	2.900	pos	Ø	n.a.
36	Madagascar	Tourist	25	42	23.300	pos	pos	S.m.
37	Ghana	Tourist	40	46	1.660	pos	pos	n.a.
38	Tanzania	Tourist	27	119	2.340	pos	pos	n.a.

(1): Time from exposure to beginning of clinical symptoms.
(2): Time from exposure to diagnostics.
(3): Less than 2 ml of Serum was available for DNA extraction.
(4): Patient evaluated for liver transplantation due to known Hepatitis B Virus infection and eosinophilia after visiting her family.
(5): Patient with meningitis and eosinophils in cerebrospinal fluid, Schistosoma DNA detected by PCR in cerebrospinal fluid.
VFR Visiting relatives and friends.
n.a. Not available.
pos Positive.
Ø Negative.
(pos) Only one of two different serological tests for schistosomiasis shows a positive result.
S.m. eggs of S.mansoni.

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ISSN: 1471-2334

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