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Table 4 Cox proportional hazards analysis of factors associated with TB among people living with HIV/AIDS in the ClinSurv HIV Cohort, Germany 2001–2011

From: Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: long-term incidence and risk factors

Predictor variable

Patients never started cART*

Patients on cART†

 

HR [95% CI]

Pvalue

HR [95% CI]

Pvalue

Gender

    

   Female

1

 

1

 

   Male

0.73 [0.36-1.47]

0.38 (NS)

1.49 [0.84- 2.62]

0.17 (NS)

Median age, years

    

   ≤38

1

 

1

 

   >38

0.86 [0.47-1.58]

0.62 (NS)

1.42 0.89 2.27

0.14 (NS)

Region of origin

    

   Germany

1

 

1

 

   Sub-Saharan Africa

4.05 [1.87-8.78]

<0.001

5.15 [2.76-9.60]

<0.001

   Other countries

1.75 [0.81-38.1]

0.16

2.22 [1.18-4.20]

0.014

HIV-transmission risk group

    

   Others†

1

 

1

 

   MSM

0.68 [0.31-1.51]

0.34

0.60 [0.32-1.10]

0.10 (NS)

CD4+ cell count (cells/μl)

    

   ≥200

1

 

1

 

   <200

8.22 [4.36-15.51]

<0.001

1.90 [1.14-3.15]

0.013

Viral load (log10 copies/ml)

    

   < 5

1

 

1

 

   ≥ 5

2.51 [1.33-4.75]

0.005

1.77 [1.11-2.82]

0.016

  1. HR, hazard ratio; CI, confidence interval; NS, non-significant; MSM, men who have sex with men.
  2. *50 TB cases among 1,919 subjects. †78 TB cases among 6,357 subjects.
  3. †Others included heterosexual, blood transfusion and mother to child transmission.
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BMC Infectious Diseases

ISSN: 1471-2334

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